Observational studyWorld journal of gastroenterology2016
Association between serum α-L-fucosidase and non-alcoholic fatty liver disease: Cross-sectional study.
Observational study in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Machine learning predicts post-transplant muscle loss in hepatocellular carcinoma patients without sarcopenia.BMC cancer · 2025Article
- Fetal manipulation of maternal metabolism is a critical function of the imprinted Igf2 gene.Cell metabolism · 2023Article
- Association between circulating cystatin C and hyperuricemia: a cross-sectional study.Clinical rheumatology · 2022Article
- Low serum vitamin D concentrations are associated with obese but not lean NAFLD: a cross-sectional study.Nutrition journal · 2021Article
- Association between High-Density Lipoprotein Cholesterol to Apolipoprotein A-I Ratio and Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study.International journal of endocrinology · 2021Article
- Association between Monocyte to High-Density Lipoprotein Cholesterol Ratio and Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study.Mediators of inflammation · 2021Article
- A predictive model for the diagnosis of non-alcoholic fatty liver disease based on an integrated machine learning method.American journal of translational research · 2021Article
- Development and validation of a clinical and laboratory-based nomogram to predict nonalcoholic fatty liver disease.Hepatology international · 2020Article
- Association between Serum Uric Acid to HDL-Cholesterol Ratio and Nonalcoholic Fatty Liver Disease in Lean Chinese Adults.International journal of endocrinology · 2020Article
- Association between dietary iron intake and the prevalence of nonalcoholic fatty liver disease: A cross-sectional study.Medicine · 2019Article
- Association of blood pressure level with nonalcoholic fatty liver disease in nonhypertensive population: Normal is not the new normal.Medicine · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo explore the association between serum α-L-fucosidase (AFU) and non-alcoholic fatty liver disease (NAFLD).
methodsA total of 16473 individuals (9456 men and 7017 women) were included in the current study, who presented for a health examination at the First Affiliated Hospital of Zhejiang University School of Medicine in 2014. The baseline characteristics of the cohort were compared by NAFLD status. Linear regression analysis and stepwise multiple regression analysis were applied to assess the risk factors for NAFLD. Receiver operating characteristic curve was used to determine the sensitivity and specificity of AFU in the diagnosis of NAFLD.
resultsThe prevalence rates of NAFLD and metabolic syndrome (MetS) were 38.0% and 25.4%, respectively. The NAFLD group had significantly higher AFU levels than the non-NAFLD group (28.7 ± 7.9 U/L vs 26.0 ± 7.3 U/L, P < 0.001) and the prevalence rate of NAFLD increased with progressively higher serum AFU levels. AFU was positively correlated with MetS and its five components: central obesity, hypertriglyceridemia, low high-density lipoprotein cholesterol, and elevated blood pressure and fasting glucose. Stepwise multiple logistic regression analysis showed that AFU was associated with an increased risk of NAFLD (OR = 1.009, 95%CI: 1.003-1.014, P < 0.001). The best cut-off value of AFU for the diagnosis of NAFLD was 27.5 U/L. The area under the curve (diagnostic efficacy index) was 0.606. The sensitivity and specificity were 54.6% and 61.8%, respectively.
conclusionAFU level is significantly associated with NAFLD, and elevated AFU level is an independent risk factor for NAFLD.
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