Observational studyWorld journal of gastroenterology2016
Italian survey on non-steroidal anti-inflammatory drugs and gastrointestinal bleeding in children.
Observational study in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 84 citations in OpenAlex.
- The use and misuse of non-steroidal anti-inflammatory drugs (Ibuprofen) and paracetamol among mothers who presented with their children in health facilities in Enugu, South‒East Nigeria.BMC public health · 2026Article
- The Effectiveness of Child Life Services in Reducing Pediatric Procedural Pain: A Systematic Review and Three-Level Meta-Analysis.Journal of pain research · 2026Review
- Efficacy and Safety of Paracetamol and NSAIDs for Fever and Pain Management in Children with Chronic Diseases: A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Histological and Biochemical Assessment of Camel Milk in Protective and Therapeutic Aspirin-Induced Gastric and Liver Damage in Rabbits.Veterinary medicine international · 2026Article
- Adverse reactions to acetaminophen and ibuprofen in pediatric patients: a narrative review.Italian journal of pediatrics · 2025Review
- An infant with Kawasaki disease having gastrointestinal bleeding due to multiple gastric ulcers.Journal of general and family medicine · 2025Article
- Assessment of non-steroidal anti-inflammatory drugs use and its complications among pediatric patients at a private tertiary care hospital in Malaysia.BMC pediatrics · 2025Article
- New perspectives for optimizing fever and pain management in pediatrics: evidence supporting therapeutic awareness in clinical practice.Italian journal of pediatrics · 2025Review
- Self-medication with NSAIDs and purchase of branded and over-the-counter medicines: Analysis of a national survey in Peru.Journal of public health research · 2025Article
- Trends in Upper Gastrointestinal Bleeding in Children: The Impact ofAntibiotics (Basel, Switzerland) · 2024Article
- Gastrointestinal bleeding in children: diagnostic approach.Italian journal of pediatrics · 2024Review
- [The challenges of managing thoracic pain in cystic fibrosis (CF)].Schmerz (Berlin, Germany) · 2022Review
- Efficacy and Safety of NSAIDs in Infants: A Comprehensive Review of the Literature of the Past 20 Years.Paediatric drugs · 2022Review
- Role of Radiology and Laparoscopy in Childhood Peptic Ulcer Perforation.Journal of environmental and public health · 2022Article
- Aqueous Ginger (BioMed research international · 2022Article
- Prescribing patterns, indications and adverse events of ibuprofen in children: results from a national survey among Italian pediatricians.Italian journal of pediatrics · 2021Article
- Ibuprofen Increases the Hepatotoxicity of Ethanol through Potentiating Oxidative Stress.Biomolecules & therapeutics · 2021Article
- Serious infectious events and ibuprofen administration in pediatrics: a narrative review in the era of COVID-19 pandemic.Italian journal of pediatrics · 2021Review
- Dictionary Learning-Based Ultrasound Image Combined with Gastroscope for Diagnosis of Helicobacter pylori-Caused Gastrointestinal Bleeding.Computational and mathematical methods in medicine · 2021Article
- The incidence of collagen-associated adverse events in pediatric population with the use of fluoroquinolones: a nationwide cohort study in Taiwan.BMC pediatrics · 2020Article
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate gastrointestinal complications associated with non-steroidal anti-inflammatory drug (NSAIDs) use in children.
methodsA retrospective, multicenter study was conducted between January 2005 and January 2013, with the participation of 8 Italian pediatric gastroenterology centers. We collected all the cases of patients who refer to emergency room for suspected gastrointestinal bleeding following NSAIDs consumption, and underwent endoscopic evaluation. Previous medical history, associated risk factors, symptoms and signs at presentation, diagnostic procedures, severity of bleeding and management of gastrointestinal bleeding were collected. In addition, data regarding type of drug used, indication, dose, duration of treatment and prescriber (physician or self-medication) were examined.
resultsFifty-one patients, including 34 males, were enrolled (median age: 7.8 years). Ibuprofen was the most used NSAID [35/51 patients (68.6%)]. Pain was the most frequent indication for NSAIDs use [29/51 patients (56.9%)]. Seven patients had positive family history of Helicobacter pylori (H. pylori) infection or peptic ulcer, and 12 had associated comorbidities. Twenty-four (47%) out of 51 patients used medication inappropriately. Hematemesis was the most frequent symptom (33.3%). Upper gastrointestinal endoscopy revealed gastric lesions in 32/51 (62%) patients, duodenal lesions in 17 (33%) and esophageal lesions in 8 (15%). In 10/51 (19.6%) patients, a diagnosis of H. pylori gastritis was made. Forty-eight (94%) patients underwent medical therapy, with spontaneous bleeding resolution, while in 3/51 (6%) patients, an endoscopic hemostasis was needed.
conclusionThe data collected in this study confirms that adverse events with the involvement of the gastrointestinal tract secondary to NSAID use are also common in children.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.