ArticleWorld journal of gastroenterology2016
One hundred and one over-the-scope-clip applications for severe gastrointestinal bleeding, leaks and fistulas.
Article in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Clinical efficacy of the over-the-scope clip device: A systematic review.World journal of gastroenterology · 2020Pooled it
- Clinical outcomes of over-the-scope-clip system for the treatment of acute upper non-variceal gastrointestinal bleeding: a systematic review and meta-analysis.BMC gastroenterology · 2019Pooled it
- Laparoscopic vs. open surgery for the treatment of iatrogenic colonoscopic perforations: a systematic review and meta-analysis.World journal of emergency surgery : WJES · 2017Pooled it
- Article
- Efficacy and safety of through-the-scope twin clip for endoscopic closure of gastrointestinal defects.Frontiers in medicine · 2026Article
- Endoloop-assisted endoscopic removal of over-the-scope and full-thickness resection device clips: Prospective study.Endoscopy international open · 2026Article
- Endoscopic Closure Techniques for Perforations, Leaks, and Fistulae: Review Article.GE Portuguese journal of gastroenterology · 2025Review
- Advancing hemostasis: A meta-analysis of novelWorld journal of gastrointestinal endoscopy · 2025Article
- Article
- Article
- Endoscopic Treatment of Duodenocolic Fistula Caused by Migrating Biliary Stents.The American journal of case reports · 2024Article
- Prophylactic clipping using the over-the-scope clip (OTSC) system after complex ESD and EMR of large colon polyps.Surgical endoscopy · 2023Article
- Endoscopic Management for Post-Surgical Complications after Resection of Esophageal Cancer.Cancers · 2022Review
- Over-the-Scope Clip Applications as First-Line Therapy in the Treatment of Upper Non-variceal Gastrointestinal Bleeding, Perforations, and Fistulas.Frontiers in medicine · 2022Article
- Colon Sparing Endoscopic Full-Thickness Resection for Advanced Colorectal Lesions: Is It Time for Global Adoption?Frontiers in oncology · 2022Article
- A Single-Center Case Series of Endoscopically Treated Aorto-Gastrointestinal Fistula after Endovascular Aortic Repair: Surgery Is Still the Only Valid Solution.Visceral medicine · 2021Article
- Use of over-the-scope clip for ulcer hemostasis after failure of both surgery and interventional therapy: A case report.Medicine · 2020Article
- Simulation-Based Mastery Learning for Practicing Gastroenterologists-Renewed Importance in the Era of COVID-19.The American journal of gastroenterology · 2020Review
- Bleeding malignant gastric ulcer: successful endoscopic hemostasis with an over-the-scope clip.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2020Article
- Endoscopic advances in the management of non-variceal upper gastrointestinal bleeding: A review.World journal of gastrointestinal endoscopy · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the efficacy and clinical outcome of patients treated with an over-the-scope-clip (OTSC) system for severe gastrointestinal hemorrhage, perforations and fistulas.
methodsFrom 02-2009 to 10-2012, 84 patients were treated with 101 OTSC clips. 41 patients (48.8%) presented with severe upper-gastrointestinal (GI) bleeding, 3 (3.6%) patients with lower-GI bleeding, 7 patients (8.3%) underwent perforation closure, 18 patients (21.4%) had prevention of secondary perforation, 12 patients (14.3%) had control of secondary bleeding after endoscopic mucosal resection or endoscopic submucosal dissection (ESD) and 3 patients (3.6%) had an intervention on a chronic fistula.
resultsIn 78/84 patients (92.8%), primary treatment with the OTSC was technically successful. Clinical primary success was achieved in 75/84 patients (89.28%). The overall mortality in the study patients was 11/84 (13.1%) and was seen in patients with life-threatening upper GI hemorrhage. There was no mortality in any other treatment group. In detail OTSC application lead to a clinical success in 35/41 (85.36%) patients with upper GI bleeding and in 3/3 patients with lower GI bleeding. Technical success of perforation closure was 100% while clinical success was seen in 4/7 cases (57.14%) due to attendant circumstances unrelated to the OTSC. Technical and clinic success was achieved in 18/18 (100%) patients for the prevention of bleeding or perforation after endoscopic mucosal resection and ESD and in 3/3 cases of fistula closure. Two application-related complications were seen (2%).
conclusionThis largest single center experience published so far confirms the value of the OTSC for GI emergencies and complications. Further clinical experience will help to identify optimal indications for its targeted and prophylactic use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.