Evidence map›Paper›PMID 26855467›Full record

ArticleProceedings of SPIE--the International Society for Optical Engineering2015

Estimation of Tissue Optical Parameters with Hyperspectral Imaging and Spectral Unmixing.

Guolan Lu, Xulei Qin, Dongsheng Wang, Zhuo Georgia Chen, Baowei Fei

Abstract read
In one paragraph

Article in Proceedings of SPIE--the International Society for Optical Engineering, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Retina Phantom Model for Hyperspectral Imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Biomedical optics express · 2024
    Article
  10. A Video Transformer Network for Thyroid Cancer Detection on Hyperspectral Histologic Images.Proceedings of SPIE--the International Society for Optical Engineering · 2023
    Article
  11. Article
  12. Article
  13. Development of a new polarized hyperspectral imaging microscope.Proceedings of SPIE--the International Society for Optical Engineering · 2020
    Article
  14. Retinal oximetry and fractal analysis of capillary maps in sickle cell disease patients and matched healthy volunteers.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020
    Observational
  15. Article
  16. Article
  17. Article
  18. Hyperspectral Imaging of Neoplastic Progression in a Mouse Model of Oral Carcinogenesis.Proceedings of SPIE--the International Society for Optical Engineering · 2016
    Article
  19. Article
  20. Polarized Hyperspectral Microscopic Imaging for Zebrafish.Proceedings of SPIE--the International Society for Optical Engineering
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Guolan LuThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA.
Xulei QinDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, GA.
Dongsheng WangDepartment of Hematology and Medical Oncology, Emory University, Atlanta, GA.
Zhuo Georgia ChenDepartment of Hematology and Medical Oncology, Emory University, Atlanta, GA.
Baowei FeiThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA; Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA; Department of Mathematics & Computer Science, Emory University, Atlanta, GA; Winship Cancer Institute of Emory University, Atlanta, GA.

Funding

uPAR Targeted in Vivo Molecular Magnetic Resonance Imaging of....P50CA128301 · NCI · EMORY UNIVERSITY · PI SCHUSTER, DAVID MICHAEL · 2008 to 2012
$6.8M
MOLECULAR IMAGING DIRECTED, 3D ULTRASOUND-GUIDED, BIOPSY SYSTEMR01CA156775 · NCI · UNIVERSITY OF TEXAS DALLAS · PI FEI, BAOWEI · 2011 to 2016
$1.7M
Targeted fusion biopsy using anti-[18F]FACBC PET/CT and real-time 3D ultrasound gR21CA176684 · NCI · EMORY UNIVERSITY · PI FEI, BAOWEI, MASTER, VIRAJ · 2013 to 2014
$568k
NCI NIH HHS P50 CA128301NCI NIH HHS R01 CA156775NCI NIH HHS R21 CA176684
6 · The paper itself

Abstract

Early detection of oral cancer and its curable precursors can improve patient survival and quality of life. Hyperspectral imaging (HSI) holds the potential for noninvasive early detection of oral cancer. The quantification of tissue chromophores by spectral unmixing of hyperspectral images could provide insights for evaluating cancer progression. In this study, non-negative matrix factorization has been applied for decomposing hyperspectral images into physiologically meaningful chromophore concentration maps. The approach has been validated by computer-simulated hyperspectral images and in vivo tumor hyperspectral images from a head and neck cancer animal model.

Indexed as

early cancer detectionHyperspectral imagingnon-negative matrix factorizationspectral unmixing

Identifiers

PMID26855467
PMCPMC4737955

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.