ArticleNature methods2016
Sensory and optogenetically driven single-vessel fMRI.
Article in Nature methods, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 125 citations in OpenAlex.
- UltraFast Layer-Resolved Encoding (uFLARE) functional MRI deciphers bidirectional signaling from spontaneous activity.Nature communications · 2026Article
- Whole-brain meso-vein imaging in living humans using fast 7-T MRI.Science advances · 2026Article
- Biophysical simulations of fMRI responses using realistic microvascular models: Insights into distinct hemodynamics in humans and mice.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Brain-wide resting-state fMRI network dynamics elicited by activation of single thalamic input.Nature communications · 2025Article
- MR perfusion source mapping depicts venous territories and reveals perfusion modulation during neural activation.Nature communications · 2025Article
- Neuromodulation in Small Animal fMRI.Journal of magnetic resonance imaging : JMRI · 2025Review
- Elucidating hemodynamics and neuro-glio-vascular signaling using rodent fMRI.Trends in neurosciences · 2025Review
- High-resolution awake mouse fMRI at 14 tesla.eLife · 2025Article
- Charting the path in rodent functional neuroimaging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- High-resolution perfusion imaging in rodents using pCASL at 9.4 T.NMR in biomedicine · 2025Article
- High-resolution awake mouse fMRI at 14 Tesla.bioRxiv : the preprint server for biology · 2024Article
- High Spatiotemporal Resolution Radial Encoding Single-Vessel fMRI.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Imaging bioluminescence by detecting localized haemodynamic contrast from photosensitized vasculature.Nature biomedical engineering · 2024Article
- The contribution of the vascular architecture and cerebrovascular reactivity to the BOLD signal formation across cortical depth.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- No replication of direct neuronal activity-related (DIANA) fMRI in anesthetized mice.Science advances · 2024Article
- Distinct neurochemical influences on fMRI response polarity in the striatum.Nature communications · 2024Article
- Characterisation of laminar and vascular spatiotemporal dynamics of CBV and BOLD signals using VASO and ME-GRE at 7T in humans.bioRxiv : the preprint server for biology · 2024Article
- Implementation of 2D Line scanning Method.Aperture neuro · 2024Article
- Characterisation of laminar and vascular spatiotemporal dynamics of CBV and BOLD signals using VASO and ME-GRE at 7T in humans.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- The Venular Side of Cerebral Amyloid Angiopathy: Proof of Concept of a Neglected Issue.Biomedicines · 2023Review
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Magnetic resonance imaging (MRI) sensitivity approaches vessel specificity. We developed a single-vessel functional MRI (fMRI) method to image the contribution of vascular components to blood oxygenation level-dependent (BOLD) and cerebral blood volume (CBV) fMRI signal. We mapped individual vessels penetrating the rat somatosensory cortex with 100-ms temporal resolution by MRI with sensory or optogenetic stimulation. The BOLD signal originated primarily from venules, and the CBV signal from arterioles. The single-vessel fMRI method and its combination with optogenetics provide a platform for mapping the hemodynamic signal through the neurovascular network with specificity at the level of individual arterioles and venules.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.