Evidence map›Paper›PMID 26855336›Full record

ArticleThe European journal of neuroscience2016

Complementary subicular pathways to the anterior thalamic nuclei and mammillary bodies in the rat and macaque monkey brain.

Kat Christiansen, Christopher M Dillingham, Nicholas F Wright, Richard C Saunders, Seralynne D Vann, John P Aggleton

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The European journal of neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
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  13. The anterior thalamic nuclei and cognition: A role beyond space?Neuroscience and biobehavioral reviews · 2021
    Review
  14. Review
  15. Article
  16. Deconstructing the Direct Reciprocal Hippocampal-Anterior Thalamic Pathways for Spatial Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  17. Article
  18. Article
  19. The Cognitive Thalamus as a Gateway to Mental Representations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Kat ChristiansenSchool of Psychology, Cardiff University, Tower Building 70, Park Place, Cardiff, CF10 3AT, UK.
Christopher M DillinghamSchool of Psychology, Cardiff University, Tower Building 70, Park Place, Cardiff, CF10 3AT, UK.
Nicholas F WrightSchool of Psychology, Cardiff University, Tower Building 70, Park Place, Cardiff, CF10 3AT, UK.
Richard C SaundersLaboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD, USA.
Seralynne D VannSchool of Psychology, Cardiff University, Tower Building 70, Park Place, Cardiff, CF10 3AT, UK.
John P AggletonSchool of Psychology, Cardiff University, Tower Building 70, Park Place, Cardiff, CF10 3AT, UK.
Cardiff University · GBNational Institute of Mental Health · US

Funding

Wellcome Trust
6 · The paper itself

Abstract

The origins of the hippocampal (subicular) projections to the anterior thalamic nuclei and mammillary bodies were compared in rats and macaque monkeys using retrograde tracers. These projections form core components of the Papez circuit, which is vital for normal memory. The study revealed a complex pattern of subicular efferents, consistent with the presence of different, parallel information streams, whose segregation appears more marked in the rat brain. In both species, the cells projecting to the mammillary bodies and anterior thalamic nuclei showed laminar separation but also differed along other hippocampal axes. In the rat, these diencephalic inputs showed complementary topographies in the proximal-distal (columnar) plane, consistent with differential involvement in object-based (proximal subiculum) and context-based (distal subiculum) information. The medial mammillary inputs, which arose along the anterior-posterior extent of the rat subiculum, favoured the central subiculum (septal hippocampus) and the more proximal subiculum (temporal hippocampus). In contrast, anterior thalamic inputs were largely confined to the dorsal (i.e. septal and intermediate) subiculum, where projections to the anteromedial nucleus favoured the proximal subiculum while those to the anteroventral nucleus predominantly arose in the distal subiculum. In the macaque, the corresponding diencephalic inputs were again distinguished by anterior-posterior topographies, as subicular inputs to the medial mammillary bodies predominantly arose from the posterior hippocampus while subicular inputs to the anteromedial thalamic nucleus predominantly arose from the anterior hippocampus. Unlike the rat, there was no clear evidence of proximal-distal separation as all of these medial diencephalic projections preferentially arose from the more distal subiculum.

Indexed as

AnimalsAnterior Thalamic NucleiHippocampusMacaca fascicularisMacaca mulattaMaleMammillary BodiesNeural PathwaysRatsSpecies Specificityanatomyfornixhippocampusmemorysubiculum

Identifiers

PMID26855336
PMCPMC4855639
OpenAlexW2256389274

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.