Evidence map›Paper›PMID 26855256›Full record

ReviewBrain research2016

Brain stimulation: Neuromodulation as a potential treatment for motor recovery following traumatic brain injury.

E Clayton, S K Kinley-Cooper, R A Weber, D L Adkins

Abstract readReview
In one paragraph

Review in Brain research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  13. Galectin-3 protects against ischemic stroke by promoting neuro-angiogenesis via apoptosis inhibition and Akt/Caspase regulation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

E ClaytonDepartment of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, United States.
S K Kinley-CooperDepartment of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, United States.
R A WeberDepartment of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, United States.
D L AdkinsDepartment of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, United States; Department of Health Sciences and Research, Medical University of South Carolina, Charleston, SC 29425, United States; Center for Biomedical Imaging, Medical University of South Carolina, Charleston, SC 29425, United States. Electronic address: adkinsdl@musc.edu.

Funding

Cortical Stimulation to Enhance Motor Recovery Following Traumatic Brain InjuryR01NS065866 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI ADKINS, DEANNA L · 2011 to 2015
$1.2M
NINDS NIH HHS R01 NS065866
6 · The paper itself

Abstract

There is growing evidence that electrical and magnetic brain stimulation can improve motor function and motor learning following brain damage. Rodent and primate studies have strongly demonstrated that combining cortical stimulation (CS) with skilled motor rehabilitative training enhances functional motor recovery following stroke. Brain stimulation following traumatic brain injury (TBI) is less well studied, but early pre-clinical and human pilot studies suggest that it is a promising treatment for TBI-induced motor impairments as well. This review will first discuss the evidence supporting brain stimulation efficacy derived from the stroke research field as proof of principle and then will review the few studies exploring neuromodulation in experimental TBI studies. This article is part of a Special Issue entitled SI:Brain injury and recovery.

Indexed as

Motor ActivityRecovery of FunctionAnimalsBrain Injuries, TraumaticDeep Brain StimulationHumansNeurological RehabilitationTranscranial Direct Current StimulationTranscranial Magnetic StimulationEpidural stimulationMotor cortexRehabilitative trainingTranscranial direct stimulation (tDCS)Transcranial stimulation (TMS)

Identifiers

PMID26855256
PMCPMC5090977

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.