Evidence map›Paper›PMID 26855003›Full record

ArticlePsychoneuroendocrinology2016

Fetal exposure to placental corticotropin-releasing hormone is associated with child self-reported internalizing symptoms.

Mariann A Howland, Curt A Sandman, Laura M Glynn, Cheryl Crippen, Elysia Poggi Davis

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychoneuroendocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 43 citations in OpenAlex.

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  19. Prenatal stress and enhanced developmental plasticity.Journal of neural transmission (Vienna, Austria : 1996) · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Mariann A HowlandDepartment of Psychiatry and Human Behavior, University of California, Irvine, CA, USA. Electronic address: mahowlan@uci.edu.
Curt A SandmanDepartment of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.
Laura M GlynnDepartment of Psychiatry and Human Behavior, University of California, Irvine, CA, USA; Department of Psychology, Chapman University, Orange, CA, USA.
Cheryl CrippenDepartment of Psychology, Chapman University, Orange, CA, USA.
Elysia Poggi DavisDepartment of Psychiatry and Human Behavior, University of California, Irvine, CA, USA; Department of Psychology, University of Denver, Denver, CO, USA.
Chapman University · USUniversity of California, Irvine · USUniversity of Denver · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Structural & Network-Function Correlates of Fragmented Early-Life Across SpeciesP50MH096889 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BARAM, TALLIE Z. · 2013 to 2023
$25.4M
Maternal Stress and Fetal/Infant DevelopmentR01NS041298 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMAN, CURT ALAN · 2002 to 2006
$2.8M
Fetal Programming of Early DevelopmentR01HD051852 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMAN, CURT ALAN · 2006 to 2010
$2.7M
NCATS NIH HHS UL1 TR001414NICHD NIH HHS HD51852NICHD NIH HHS R01 HD051852NIMH NIH HHS MH-96889NIMH NIH HHS P50 MH096889NINDS NIH HHS NS41298NINDS NIH HHS R01 NS041298
6 · The paper itself

Abstract

objectiveFetal exposure to maternal prenatal stress hormones such as cortisol exerts influences on the developing nervous system that persist and include risk for internalizing symptoms later in life. Placental corticotropin-releasing hormone (pCRH) is a feto-placental stress signal that also shapes fetal neurodevelopment and may be a more direct indicator of the fetal experience than maternal stress hormones. The programming effects of pCRH on child development are unknown. The current investigation examined associations between prenatal maternal and placental stress hormone exposures (maternal cortisol and pCRH) and child self-reported internalizing symptoms at age 5.

methodMaternal plasma cortisol and pCRH levels were measured at 15, 19, 25, 31, and 36 weeks' gestation in a sample of 83 women and their 91 children (8 sibling pairs from separate pregnancies), who were born full-term. Child self-reported internalizing symptoms at age 5 were obtained using scales of the Berkeley Puppet Interview.

resultsPlacental CRH profiles (including elevations in mid-gestation) were associated with higher levels of internalizing symptoms at age 5. This effect was not explained by critical prenatal or postnatal influences, including obstetric risk, concurrent maternal psychological state, and family socio-economic status. Prenatal maternal cortisol was not significantly associated with child self-reported internalizing symptoms.

conclusionsFindings suggest that elevated exposures to the feto-placental stress signal pCRH exert programming effects on the developing fetal central nervous system, with lasting consequences for child mental health.

Indexed as

Internal-External ControlPrenatal Exposure Delayed EffectsSelf ReportAdultChild, PreschoolCorticotropin-Releasing HormoneFemaleFetal BloodHumansHydrocortisoneMalePlacentaPregnancyCorticotropin-Releasing HormoneHydrocortisoneCortisolCRHFetal programmingInternalizing problemsPregnancyPrenatal

Identifiers

PMID26855003
PMCPMC4808336
OpenAlexW2285377267

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.