ArticleNucleus (Austin, Tex.)2016
Exploring chromatin organization mechanisms through its dynamic properties.
Article in Nucleus (Austin, Tex.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
- Increased Telomere Mobility in Progeria is Restored by Isoprenylcysteine Carboxyl Methyltransferase Inhibition.bioRxiv : the preprint server for biology · 2026Article
- Scale-free models of chromosome structure, dynamics, and mechanics.PNAS nexus · 2025Article
- Single nucleosome imaging reveals principles of transient multiscale chromatin reorganization triggered by histone ADP-ribosylation at DNA lesions.Nature communications · 2025Article
- Cellular and Nuclear Forces: An Overview.Methods in molecular biology (Clifton, N.J.) · 2025Review
- Article
- Trajectory Analysis in Single-Particle Tracking: From Mean Squared Displacement to Machine Learning Approaches.International journal of molecular sciences · 2024Review
- Chromatin phase separated nanoregions explored by polymer cross-linker models and reconstructed from single particle trajectories.PLoS computational biology · 2024Article
- Article
- Fast and parallel nanoscale three-dimensional tracking of heterogeneous mammalian chromatin dynamics.Molecular biology of the cell · 2022Article
- Olfactory receptor choice: a case study for gene regulation in a multi-enhancer system.Current opinion in genetics & development · 2022Review
- Parp1 promotes sleep, which enhances DNA repair in neurons.Molecular cell · 2021Article
- Discrete cis-acting element regulates developmentally timed gene-lamina relocation and neural progenitor competence in vivo.Developmental cell · 2021Article
- Plant 3D genomics: the exploration and application of chromatin organization.The New phytologist · 2021Review
- Article
- The Dynamics of Lamin a During the Cell Cycle.Frontiers in molecular biosciences · 2021Article
- Review
- Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons.Nature communications · 2019Article
- Evidence That Ion-Based Signaling Initiating at the Cell Surface Can Potentially Influence Chromatin Dynamics and Chromatin-Bound Proteins in the Nucleus.Frontiers in plant science · 2019Article
- Finding Friends in the Crowd: Three-Dimensional Cliques of Topological Genomic Domains.Frontiers in genetics · 2019Review
- Heterochromatin restricts the mobility of nuclear bodies.Chromosoma · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The organization of the genome in the nucleus is believed to be crucial for different cellular functions. It is known that chromosomes fold into distinct territories, but little is known about the mechanisms that maintain these territories. To explore these mechanisms, we used various live-cell imaging methods, including single particle tracking to characterize the diffusion properties of different genomic regions in live cells. Chromatin diffusion is found to be slow and anomalous; in vast contrast, depletion of lamin A protein significantly increases chromatin motion, and the diffusion pattern of chromatin transforms from slow anomalous to fast normal. More than this, depletion of lamin A protein also affects the dynamics of nuclear bodies. Our findings indicate that chromatin motion is mediated by lamin A and we suggest that constrained chromatin mobility allows to maintain chromosome territories. Thus, the discovery of this function of nucleoplasmic lamin A proteins sheds light on the maintenance mechanism of chromosome territories in the interphase nucleus, which ensures the proper function of the genome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.