ArticleNeurobiology of learning and memory2016
Distinct medial temporal networks encode surprise during motivation by reward versus punishment.
Article in Neurobiology of learning and memory, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neural correlates of uncertainty processing: meta-analysis of fMRI studies.Frontiers in neuroscience · 2025Pooled it
- A meta-analysis of the neural substrates of monetary reward anticipation and outcome in alcohol use disorder.Human brain mapping · 2023Pooled it
- Kisspeptin enhances brain responses to olfactory and visual cues of attraction in men.JCI insight · 2020Trial
- Diverging influences of punishment motivation and negative affect on cognitive control.Cognitive, affective & behavioral neuroscience · 2026Article
- Source-based morphometry analyses yield associations between large-scale structural brain networks and psychopathic traits in incarcerated adolescents.Frontiers in psychology · 2026Article
- Reward masks the learning of cognitive control demand.Cognitive neurodynamics · 2025Article
- More widespread and rigid neuronal representation of reward expectation underlies impulsive choices.bioRxiv : the preprint server for biology · 2024Article
- Electome network factors: Capturing emotional brain networks related to health and disease.Cell reports methods · 2024Review
- The Emerging Therapeutic Potential of Kisspeptin and Neurokinin B.Endocrine reviews · 2024Review
- Long-term, multi-event surprise correlates with enhanced autobiographical memory.Nature human behaviour · 2023Article
- Contributions of transient and sustained reward to memory formation.Psychological research · 2023Article
- Switching between External and Internal Attention in Hippocampal Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Instructed motivational states bias reinforcement learning and memory formation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Reward, motivation and brain imaging in human healthy participants - A narrative review.Frontiers in behavioral neuroscience · 2023Review
- Reward Uncertainty and Expected Value Enhance Generalization of Episodic Memory.International journal of environmental research and public health · 2022Article
- The role of discriminability in face perception: Interference processing of expression, gender, and gaze.Attention, perception & psychophysics · 2022Article
- Hypothalamic Functional Connectivity and Apathy in People with Alzheimer's Disease and Cognitively Normal Healthy Controls.Journal of Alzheimer's disease : JAD · 2022Article
- Current Perspectives on Kisspeptins Role in Behaviour.Frontiers in endocrinology · 2022Review
- In for a penny, in for a pound: examining motivated memory through the lens of retrieved context models.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Mnemonic prediction errors promote detailed memories.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
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3 authors.
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Abstract
Adaptive motivated behavior requires predictive internal representations of the environment, and surprising events are indications for encoding new representations of the environment. The medial temporal lobe memory system, including the hippocampus and surrounding cortex, encodes surprising events and is influenced by motivational state. Because behavior reflects the goals of an individual, we investigated whether motivational valence (i.e., pursuing rewards versus avoiding punishments) also impacts neural and mnemonic encoding of surprising events. During functional magnetic resonance imaging (fMRI), participants encountered perceptually unexpected events either during the pursuit of rewards or avoidance of punishments. Despite similar levels of motivation across groups, reward and punishment facilitated the processing of surprising events in different medial temporal lobe regions. Whereas during reward motivation, perceptual surprises enhanced activation in the hippocampus, during punishment motivation surprises instead enhanced activation in parahippocampal cortex. Further, we found that reward motivation facilitated hippocampal coupling with ventromedial PFC, whereas punishment motivation facilitated parahippocampal cortical coupling with orbitofrontal cortex. Behaviorally, post-scan testing revealed that reward, but not punishment, motivation resulted in greater memory selectivity for surprising events encountered during goal pursuit. Together these findings demonstrate that neuromodulatory systems engaged by anticipation of reward and punishment target separate components of the medial temporal lobe, modulating medial temporal lobe sensitivity and connectivity. Thus, reward and punishment motivation yield distinct neural contexts for learning, with distinct consequences for how surprises are incorporated into predictive mnemonic models of the environment.
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