SynthesisNature neuroscience2016
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Nature neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 9 of them syntheses that pooled it.
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124citing papers in PubMed, 9 pooled it
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What it found
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Who cites it
124 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- Linking Polygenic Risk of Schizophrenia to Variation in Magnetic Resonance Imaging Brain Measures: A Comprehensive Systematic Review.Schizophrenia bulletin · 2024Pooled it
- Identifying genes associated with brain volumetric differences through tissue specific transcriptomic inference from GWAS summary data.BMC bioinformatics · 2022Pooled it
- Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11.2 deletion syndrome: A review of ENIGMA findings.Psychiatry and clinical neurosciences · 2022Pooled it
- Genetic factors influencing a neurobiological substrate for psychiatric disorders.Translational psychiatry · 2021Pooled it
- ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries.Translational psychiatry · 2020Pooled it
- The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder.Biological psychiatry · 2019Pooled it
- Genetic Markers of ADHD-Related Variations in Intracranial Volume.The American journal of psychiatry · 2019Pooled it
- Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume.Nature communications · 2018Pooled it
- Brain imaging genetics in ADHD and beyond - Mapping pathways from gene to disorder at different levels of complexity.Neuroscience and biobehavioral reviews · 2017Pooled it
- Genetically informed dissection of multimodal brain aging and ten major psychiatric disorders.Molecular psychiatry · 2026Article
- Shared Genetic Networks in Schizophrenia and Bipolar Disorder: Hippocampal Volume-Mediated Neurobiological Mechanisms.Schizophrenia bulletin · 2026Article
- Exploration of Genetic Overlap of Brain Phenotypes With Schizophrenia: Different Methods Provide Complementary Insights.Schizophrenia bulletin · 2026Article
- Shared genetic architecture between ADHD and intelligence varies across ADHD subtypes.BMC medicine · 2026Article
- 'Unravelling the shared genetic architecture between suicidality and subcortical brain volume: a genome-wide association study'.Acta neuropsychiatrica · 2025Article
- Genome-wide Pleiotropy Analysis Reveals Shared Genetic Associations between Type 2 Diabetes Mellitus and Subcortical Brain Volumes.Research (Washington, D.C.) · 2025Article
- Shared Genetic Determinants of Schizophrenia and Autism Spectrum Disorder Implicate Opposite Risk Patterns: A Genome-Wide Analysis of Common Variants.Schizophrenia bulletin · 2024Article
- Genetic architectures of the human hippocampus and those involved in neuropsychiatric traits.BMC medicine · 2024Article
- Unveiling Promising Neuroimaging Biomarkers for Schizophrenia Through Clinical and Genetic Perspectives.Neuroscience bulletin · 2024Review
- Schizophrenia genomics: genetic complexity and functional insights.Nature reviews. Neuroscience · 2024Review
- Common risk alleles for schizophrenia within the major histocompatibility complex predict white matter microstructure.Translational psychiatry · 2024Article
64 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
36 authors.
Barbara Franke *Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
Jason L Stein *Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, CA, USA.
Stephan Ripke *Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Verneri AnttilaAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Derrek P HibarImaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, CA, USA.
Kimm J E van HulzenDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
Alejandro Arias-VasquezDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
Jordan W SmollerStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Thomas E NicholsFMRIB Centre, University of Oxford, United Kingdom.
Michael C NealeDepartments of Psychiatry & Human Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Andrew M McIntoshDivision of Psychiatry, Royal Edinburgh Hospital, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom.
Phil LeeStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Francis J McMahonIntramural Research Program, National Institutes of Health, US Dept of Health & Human Services, Bethesda, USA.
Andreas Meyer-LindenbergCentral Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany.
Manuel MattheisenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Ole A AndreassenNORMENT - KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Oliver GruberCenter for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry and Psychotherapy, University Medical Center, Goettingen, Germany.
Perminder S SachdevCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales (UNSW), Sydney, Australia.
Roberto Roiz-SantiañezDepartment of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, Santander, Spain.
Andrew J SaykinCenter for Neuroimaging, Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, USA.
Stefan EhrlichDepartment of Child and Adolescent Psychiatry, Faculty of Medicine and University Hospital, TU Dresden, Dresden, Germany.
Karen A MatherCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales (UNSW), Sydney, Australia.
Jessica A TurnerGeorgia State University, Atlanta, USA.
Emanuel SchwarzCentral Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany.
Anbupalam ThalamuthuCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales (UNSW), Sydney, Australia.
Yin Yao ShugartIntramural Research Program, National Institutes of Health, US Dept of Health & Human Services, Bethesda, USA.
Yvonne Yw HoQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Margaret J WrightQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Schizophrenia Working Group of the Psychiatric Genomics Consortium
ENIGMA Consortium
Michael C O'Donovan *MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, UK.
Paul M Thompson *Imaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, CA, USA.
Benjamin M Neale *Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Sarah E Medland *QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Patrick F Sullivan *Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Funding
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0MNational Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MMapping genes that contribute to bipolar disorderZIAMH002810 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MCMAHON, FRANCIS J · 2009 to 2025
$31.2MUC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3MGenomic Psychiatry CohortR01MH085548 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PATO, CARLOS N, PATO, MICHELE T · 2008 to 2012
$16.3MEPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDYR01AG008122 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 1989 to 2015
$14.4MAN NCRR CENTER FOR HIGH THROUGHPUT SNP GENOTYPING AND ANALYSIS: GAIN NETWORKU54RR020278 · NCRR · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2004 to 2008
$14.4MTR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1MCell Interactions in the Inflamed Intestinal MucosaR01DK075787 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI JOEL N HIRSCHHORN · 2007 to 2026
$13.1MTemporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
$12.3MInternational Cohort Collection for Bipolar DisorderR01MH085542 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI SMOLLER, JORDAN W · 2008 to 2012
$10.7MTraining U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MBritish Heart FoundationCCR NIH HHS NIMH RC2 MH089964Medical Research Council 93558Medical Research Council G0000934Medical Research Council G0800509Medical Research Council G0801418Medical Research Council G0901858Medical Research Council G1100616Medical Research Council MC_UU_12013/1Medical Research Council MC_UU_12013/2Medical Research Council MR/K026992/1Medical Research Council MR/L010305/1Medical Research Council MR/L016400/1Medical Research Council MR/L023784/2Medical Research Council MR/P005748/1NCRR NIH HHS RR026075NCRR NIH HHS U54 RR020278NIA NIH HHS P30 AG010129NIA NIH HHS R01 AG008122NIA NIH HHS R01 AG033193NIA NIH HHS R01 AG040060NIA NIH HHS R01AG040060NIA NIH HHS R01 AG054076NIA NIH HHS U01 AG024904NIA NIH HHS U24 AG021886NIBIB NIH HHS P41 EB015922NIBIB NIH HHS R01 EB005846NIBIB NIH HHS R01 EB006841NIBIB NIH HHS R01 EB008432NIBIB NIH HHS R01 EB020407NIBIB NIH HHS U54 EB020403NICHD NIH HHS R01 HD050735NIDDK NIH HHS R01 DK075787NIMH NIH HHS 1RC2 MH089951NIMH NIH HHS 1RC2 MH089995NIMH NIH HHS K01 MH065580NIMH NIH HHS K01 MH085812NIMH NIH HHS K01 MH099232NIMH NIH HHS K23 MH001760NIMH NIH HHS K24 MH094614NIMH NIH HHS K99 MH101367NIMH NIH HHS K99 MH102357NIMH NIH HHS K99MH102357NIMH NIH HHS MH001760NIMH NIH HHS MH061884NIMH NIH HHS MH065580NIMH NIH HHS MH068881NIMH NIH HHS MH071681NIMH NIH HHS MH081802NIMH NIH HHS MH083094NIMH NIH HHS MH085542NIMH NIH HHS MH085548NIMH NIH HHS MH 41953NIMH NIH HHS MH46276NIMH NIH HHS MH46289NIMH NIH HHS MH46318NIMH NIH HHS MH52618NIMH NIH HHS MH58693NIMH NIH HHS MH59565NIMH NIH HHS MH59566NIMH NIH HHS MH59571NIMH NIH HHS MH59586NIMH NIH HHS MH59587NIMH NIH HHS MH59588NIMH NIH HHS MH60870NIMH NIH HHS MH60879NIMH NIH HHS MH61675NIMH NIH HHS MH67257NIMH NIH HHS MH79469NIMH NIH HHS MH79470NIMH NIH HHS MH81800NIMH NIH HHS P50 MH080272NIMH NIH HHS R00 MH102357NIMH NIH HHS R01 MH041953NIMH NIH HHS R01 MH058693NIMH NIH HHS R01 MH059565NIMH NIH HHS R01 MH059566NIMH NIH HHS R01 MH059571NIMH NIH HHS R01 MH059586NIMH NIH HHS R01 MH059587NIMH NIH HHS R01 MH059588NIMH NIH HHS R01 MH060870NIMH NIH HHS R01 MH060879NIMH NIH HHS R01 MH061675NIMH NIH HHS R01 MH061884NIMH NIH HHS R01 MH062276NIMH NIH HHS R01 MH062873NIMH NIH HHS R01 MH067257NIMH NIH HHS R01 MH068881NIMH NIH HHS R01 MH068921NIMH NIH HHS R01 MH068922NIMH NIH HHS R01 MH071681NIMH NIH HHS R01 MH077139NIMH NIH HHS R01MH077139NIMH NIH HHS R01 MH078075NIMH NIH HHS R01 MH081800NIMH NIH HHS R01 MH081802NIMH NIH HHS R01 MH083094NIMH NIH HHS R01 MH084098NIMH NIH HHS R01 MH085542NIMH NIH HHS R01 MH085548NIMH NIH HHS R01 MH085667NIMH NIH HHS R01 MH089722NIMH NIH HHS R01 MH092380NIMH NIH HHS R01 MH094343NIMH NIH HHS R01 MH095034NIMH NIH HHS R01 MH097268NIMH NIH HHS R01 MH100141NIMH NIH HHS R01MH62873NIMH NIH HHS RC2 MH089951NIMH NIH HHS RC2 MH089964NIMH NIH HHS RC2 MH089995NIMH NIH HHS U01 MH046276NIMH NIH HHS U01 MH046289NIMH NIH HHS U01 MH046318NIMH NIH HHS U01 MH079469NIMH NIH HHS U01 MH079470NIMH NIH HHS U01 MH081928NIMH NIH HHS U01 MH085520NIMH NIH HHS U01 MH094421NIMH NIH HHS U01 MH109528NINDS NIH HHS R01 NS080655Wellcome Trust 068545/Z/0Wellcome Trust 068545/Z/02Wellcome Trust 072894/Z/03/ZWellcome Trust 076113/C/04/ZWellcome Trust 076113/CI04/ZWellcome Trust 085475/B/08/ZWellcome Trust 085475/Z/08/ZWellcome Trust 090532/Z/09/ZWellcome Trust 104036Wellcome Trust WT0618S8Wellcome Trust WT 083948/Z/07/Z
Abstract
Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders.
Indexed as
Genome-Wide Association StudyBrainEndophenotypesGenetic Predisposition to DiseaseHumansLinkage DisequilibriumMagnetic Resonance ImagingNeuroimagingOrgan SizePolymorphism, Single NucleotideSchizophrenia
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