ArticleJournal of psychiatry & neuroscience : JPN2016
Global brain connectivity alterations in patients with schizophrenia and bipolar spectrum disorders.
Article in Journal of psychiatry & neuroscience : JPN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 66 citations in OpenAlex.
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- Altered neurostructural development in magnetic resonance imaging-negative pediatric epilepsy: A large-scale multicenter study of 1919 children.Epilepsia · 2026Article
- Tracking dynamic EEG connectivity in schizophrenia and bipolar disorder.Scientific reports · 2025Article
- Multimodal MRI study of gray matter and functional connectivity abnormalities in adolescents with bipolar disorder.Frontiers in psychiatry · 2025Article
- Aberrant resting-state functional network centrality and cognitive impairment in unmedicated, euthymic bipolar patients.BMC psychiatry · 2024Article
- Delirium risk and mortality in people with pre-existing severe mental illness: a retrospective cohort study using linked datasets in England.Psychological medicine · 2024Article
- Mendelian randomization analyses reveal causal relationships between brain functional networks and risk of psychiatric disorders.Nature human behaviour · 2024Article
- Exploring functional dysconnectivity in schizophrenia: alterations in eigenvector centrality mapping and insights into related genes from transcriptional profiles.Schizophrenia (Heidelberg, Germany) · 2024Article
- Transcriptional signatures of the whole-brain voxel-wise resting-state functional network centrality alterations in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- Shared and distinct patterns of dynamical degree centrality in bipolar disorder across different mood states.Frontiers in psychiatry · 2022Article
- Closing the life-cycle of normative modeling using federated hierarchical Bayesian regression.PloS one · 2022Article
- A family study of symbolic learning and synaptic plasticity in autism spectrum disorder.Frontiers in human neuroscience · 2022Article
- Chinese Color Nest Project : An accelerated longitudinal brain-mind cohort.Developmental cognitive neuroscience · 2021Review
- Comparison of EEG microstates with resting state fMRI and FDG-PET measures in the default mode network via simultaneously recorded trimodal (PET/MR/EEG) data.Human brain mapping · 2021Article
- Dynamics of amygdala connectivity in bipolar disorders: a longitudinal study across mood states.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Strategies to solve the reverse inference fallacy in future MRI studies of schizophrenia: a review.Brain imaging and behavior · 2021Review
- Article
- Opposing Changes in the Functional Architecture of Large-Scale Networks in Bipolar Mania and Depression.Schizophrenia bulletin · 2020Article
- The relationship between performance in a theory of mind task and intrinsic functional connectivity in youth with early onset psychosis.Developmental cognitive neuroscience · 2019Article
- Shared and Distinct Functional Architectures of Brain Networks Across Psychiatric Disorders.Schizophrenia bulletin · 2019Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe human brain is organized into functionally distinct modules of which interactions constitute the human functional connectome. Accumulating evidence has implicated perturbations in the patterns of brain connectivity across a range of neurologic and neuropsychiatric disorders, but little is known about diagnostic specificity. Schizophrenia and bipolar disorders are severe mental disorders with partly overlapping symptomatology. Neuroimaging has demonstrated brain network disintegration in the pathophysiologies; however, to which degree the 2 diagnoses present with overlapping abnormalities remains unclear.
methodsWe collected resting-state fMRI data from patients with schizophrenia or bipolar disorder and from healthy controls. Aiming to characterize connectivity differences across 2 severe mental disorders, we derived global functional connectivity using eigenvector centrality mapping, which allows for regional inference of centrality or importance in the brain network.
resultsSeventy-one patients with schizophrenia, 43 with bipolar disorder and 196 healthy controls participated in our study. We found significant effects of diagnosis in 12 clusters, where pairwise comparisons showed decreased global connectivity in high-centrality clusters: sensory regions in patients with schizophrenia and subcortical regions in both patient groups. Increased connectivity occurred in frontal and parietal clusters in patients with schizophrenia, with intermediate effects in those with bipolar disorder. Patient groups differed in most cortical clusters, with the strongest effects in sensory regions. LIMITATIONS: Methodological concerns of in-scanner motion and the use of full correlation measures may make analyses more vulnerable to noise.
conclusionOur results show decreased eigenvector centrality of limbic structures in both patient groups and in sensory regions in patients with schizophrenia as well as increased centrality in frontal and parietal regions in both groups, with stronger effects in patients with schizophrenia.
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