ArticleThe Journal of investigative dermatology2016
Longitudinal Evaluation of the Skin Microbiome and Association with Microenvironment and Treatment in Canine Atopic Dermatitis.
Article in The Journal of investigative dermatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 175 citations in OpenAlex.
- Commensal Cutibacterium acnes-derived indolelactic acid safeguards skin barrier function through the aryl hydrocarbon receptor.Cell reports. Medicine · 2026Trial
- Clinical Efficacy of Probiotic-Based Ear Drops Containing Lactobacilli in Canine Erythroceruminous Otitis Externa: An Open Label, Multicentre Study.Veterinary dermatology · 2026Article
- Oral Administration ofAnimals : an open access journal from MDPI · 2026Article
- A Novel Topical Emollient Plus for Canine Atopic Dermatitis: A Clinical Trial Assessing Efficacy and User Acceptance.Veterinary dermatology · 2026Article
- Preventive effect of bentonite against pyoderma via direct binding capability of staphylococci.PloS one · 2026Article
- Pathogenic bacterial species and the microbiome of cat fleas (Ctenocephalides felis) inhabiting flea-infested homes.PloS one · 2026Article
- Oral probiotic and postbiotic supplementation enhances the abundance of Lactobacillus acidophilus, Lactobacillus johnsonii, and Limosilactobacillus reuteri in both canine skin and gastrointestinal microbiota: insights from long-read 16S rRNA gene sequencing.Veterinary research communications · 2025Article
- The golden jackal (Canis aureus): interaction of fur and fecal microbiota, host genetics and animal traits.Animal microbiome · 2025Article
- Effect of a standardised Ophytrium-containing shampoo and a leave-on mousse protocol on dogs with irritated and pruritic skin.The Journal of small animal practice · 2025Article
- Piezo1 balances membrane and cortex tension to stabilize intercellular junctions and maintain the epithelial barrier.Journal of cell science · 2025Article
- Antimicrobial activity of ear cleanser products against biofilm and planktonic phases of Staphylococcus spp. and Pseudomonas spp. isolated from canine skin and ear infections.BMC veterinary research · 2025Article
- Immunomodulating Effects of Heat-KilledVeterinary sciences · 2025Article
- Canine atopic dermatitis: An evolving understanding.The Canadian veterinary journal = La revue veterinaire canadienne · 2025Article
- Skin Barrier in Normal and Allergic Horses: What Do We Know?Veterinary sciences · 2025Review
- The skin microbiome on healthy and inflammatory altered canine skin determined by next generation sequencing.Frontiers in microbiology · 2025Article
- Metagenomic characterisation of canine skin reveals a core healthy skin microbiome.Scientific reports · 2024Article
- Efficacy of Chlorhexidine Impregnated Wipes for the Local Dysbiosis in Atopic Dogs: A Multicentric Prospective Study.Veterinary sciences · 2024Article
- Characterization of the skin microbiome in normal and cutaneous squamous cell carcinoma affected cats and dogs.mSphere · 2024Article
- Evaluation of the Impact of Near-Infrared Multiwavelength Locked System Laser Therapy on Skin Microbiome in Atopic Dogs.Animals : an open access journal from MDPI · 2024Article
- A Randomized Controlled Trial to Evaluate the Impact of a Novel Probiotic and Nutraceutical Supplement on Pruritic Dermatitis and the Gut Microbiota in Privately Owned Dogs.Animals : an open access journal from MDPI · 2024Article
10 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Host-microbe interactions may play a fundamental role in the pathogenesis of atopic dermatitis, a chronic relapsing inflammatory skin disorder characterized by universal colonization with Staphylococcus species. To examine the relationship between epidermal barrier function and the cutaneous microbiota in atopic dermatitis, this study used a spontaneous model of canine atopic dermatitis. In a cohort of 14 dogs with canine atopic dermatitis, the skin microbiota were longitudinally evaluated with parallel assessment of skin barrier function at disease flare, during antimicrobial therapy, and post-therapy. Sequencing of the bacterial 16S ribosomal RNA gene showed decreased bacterial diversity and increased proportions of Staphylococcus (S. pseudintermedius in particular) and Corynebacterium species compared with a cohort of healthy control dogs (n = 16). Treatment restored bacterial diversity with decreased proportions of Staphylococcus species, concurrent with decreased canine atopic dermatitis severity. Skin barrier function, as measured by corneometry, pH, and transepidermal water loss also normalized with treatment. Bacterial diversity correlated with transepidermal water loss and pH level but not with corneometry results. These findings provide insights into the relationship between the cutaneous microbiome and skin barrier function in atopic dermatitis, show the impact of antimicrobial therapy on the skin microbiome, and highlight the utility of canine atopic dermatitis as a spontaneous nonrodent model of atopic dermatitis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.