Evidence map›Paper›PMID 26854475›Full record

ArticleClinical transplantation2016

Impact of EGF, IL28B, and PNPLA3 polymorphisms on the outcome of allograft hepatitis C: a multicenter study.

Jessica L Mueller, Lindsay Y King, Kara B Johnson, Tian Gao, Lauren D Nephew, Darshan Kothari, Mary Ann Simpson, Hui Zheng, Lan Wei, Kathleen E Corey and 9 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical transplantation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 2 countries.

Jessica L MuellerDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Lindsay Y KingDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Kara B JohnsonDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Tian GaoDivision of Gastroenterology, Department of Medicine, Boston Medical Center, Boston, MA, USA.
Lauren D NephewDivision of Gastroenterology, Department of Medicine, University of Pennsylvania Health System, Philadelphia, PA, USA.
Darshan KothariHarvard Medical School, Boston, MA, USA.
Mary Ann SimpsonDivision of Gastroenterology, Department of Medicine, Lahey Hospital & Medical Center, Burlington, MA, USA.
Hui ZhengBiostatistics Center, Massachusetts General Hospital, Boston, MA, USA.
Lan WeiDivision of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.
Kathleen E CoreyDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Joseph MisdrajiDepartment of Pathology, Massachusetts General Hospital, Boston, MA, USA.
Joon Hyoek LeeDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
M Valerie LinDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Neliswa A GogelaDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Bryan C FuchsHarvard Medical School, Boston, MA, USA.
Kenneth K TanabeHarvard Medical School, Boston, MA, USA.
Fredric D GordonHarvard Medical School, Boston, MA, USA.
Michael P CurryHarvard Medical School, Boston, MA, USA.
Raymond T ChungDivision of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Harvard University · USMassachusetts General Hospital · USLahey Medical Center · USBeth Israel Deaconess Medical Center · USBoston Medical Center · USSungkyunkwan University · KRUniversity of Pennsylvania Health System · US

Funding

CLINICAL EPIDEMIOLOGY TRAINING IN GASTROENTEROLOGYT32DK007740 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI James D Lewis · 1997 to 2026
$9.2M
The Impact of Obstructive Sleep Apnea on Non-Alcoholic Fatty Liver DiseaseK23DK099422 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI COREY, KATHLEEN ELIZABETH · 2013 to 2017
$938k
NIDDK NIH HHS K23 DK099422NIDDK NIH HHS T32 DK007740
6 · The paper itself

Abstract

Hepatitis C virus (HCV) infection is accelerated following liver transplantation (LT). Single nucleotide polymorphisms (SNPs) near the epidermal growth factor (EGF) (rs4444903), IL28B (rs12979860), and PNPLA3 (rs738409) loci are associated with treatment response, fibrosis, and hepatocellular carcinoma in non-transplant hepatitis C, but allograft population data are limited. We sought to determine the role of these SNPs in 264 patients with HCV who underwent LT between 1990 and 2008. Genotypes were determined from donor wedge/allograft biopsies and recipient explants. Cox proportional hazards model was used to assess time to cirrhosis, liver-related death, and retransplantation, adjusting for donor age and sustained virological response (SVR). Over a median follow-up of 6.3 yr, a trend toward increased progression to graft cirrhosis was observed among recipients of an EGF non-AA vs. AA donor liver (adjusted HR 2.01; 95% CI 0.93-4.34; p = 0.08). No other genotypes predicted cirrhosis development or graft survival. The CC IL28B variant in both recipients and donors was associated with increased rate of SVR (R-CC/D-CC 8/12[67%], R-non-CC/D-CC or R-CC/D-non-CC 23/52[44%], R-non-CC/D-non-CC 12/45[27%], p linear trend = 0.009). Recipient EGF, IL28B, and PNPLA3, and donor IL28B and PNPLA3 genotypes do not predict adverse outcomes in HCV LT recipients. A potential association exists between donor EGF genotype and cirrhosis.

Indexed as

Liver TransplantationPostoperative ComplicationsAcyltransferasesAdultAllograftsAntiviral AgentsCarcinoma, HepatocellularCohort StudiesDisease ProgressionEpidermal Growth FactorFemaleFollow-Up StudiesGenotypeGraft RejectionGraft SurvivalHepacivirusAcyltransferasesAntiviral AgentsEpidermal Growth FactorInterferon Lambdainterferon-lambda, humanInterferonsInterleukinsLipaseMembrane ProteinsPhospholipases A2, Calcium-IndependentPNPLA3 protein, humancirrhosishepatitis C virussingle nucleotide polymorphismsustained virological responsetransplantation

Identifiers

PMID26854475
PMCPMC4868041
OpenAlexW2257968263

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.