ArticleDiagnostics (Basel, Switzerland)2015
Association between APOE ε4 Genotype and Memory Impairment in Elderly with Normal Global Cognitive Assessment.
Article in Diagnostics (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Mapping dementia research in Indonesia: A scoping review of evidence, gaps, and future directions.PLOS global public health · 2026Article
- The Impact of HIV on Early Brain Aging-A Pathophysiological (Re)View.Journal of clinical medicine · 2024Review
- Brain-derived neurotrophic factor interplay with oxidative stress: neuropathology approach in potential biomarker of Alzheimer's disease.Dementia & neuropsychologia · 2023Review
- Hypertension and Dementia: A comprehensive review from the HOPE Asia Network.Journal of clinical hypertension (Greenwich, Conn.) · 2019Review
- Aging and Apolipoprotein E in HIV Infection.Journal of neurovirology · 2018Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimEarly prediction using cognitive evaluation tools that are less influenced by education level is beneficial for dementia screening. This study investigated the relationship between Word List Memory Immediate Recall (WLM IR) and the Saving Score (SS) with having the APOE ε4 risk allele in the elderly with normal global cognitive assessment.
methodsA cross-sectional study on 105 subjects ≥60 years with normal MMSE scores who met inclusion criteria. Memory impairment (MI) if: WLM IR score on the third trial <8 or an SS score <80%.
resultsThe majority of the subjects were female (68.6%), 65 ± 7.1 years, had undertaken formal education for <6 years (56.2%), had MI (81%), and the APOE ε4 genotype was detected in 24.8% of subjects. There was a significant relationship between APOE ε4 and lower WLMIR (p = 0.02, OR 7.92, CI 95% (1.00-62.38)).
conclusionsWLM IR score is lower in elderly people with the APOE ε4 despite their normal global cognitive assessment results, and these scores were not influenced by education level. Further research needs to confirm that the WLM IR can be used to screen for early dementia.
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