Evidence map›Paper›PMID 26854071›Full record

ArticleFungal genetics and biology : FG & B2016

High frame-rate resolution of cell division during Candida albicans filamentation.

Darren D Thomson, Judith Berman, Alexandra C Brand

Open access · hybridAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Fungal genetics and biology : FG & B, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Candida albicans Hyphae: From Growth Initiation to Invasion.Journal of fungi (Basel, Switzerland) · 2018
    Review
  5. Network-based approaches to quantify multicellular development.Journal of the Royal Society, Interface · 2017
    Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Darren D ThomsonManchester Fungal Infection Group, Institute of Inflammation and Repair, University of Manchester, CTF Building, Grafton Street, Manchester M13 9NT, UK.
Judith BermanDepartment of Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv 69978, Israel.
Alexandra C BrandSchool of Medicine, Medical Sciences & Nutrition, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK. Electronic address: a.brand@aberdeen.ac.uk.
Tel Aviv University · ILUniversity of Aberdeen · GBUniversity of Manchester · GB

Funding

Biotechnology and Biological Sciences Research Council BB/F016964/1Medical Research Council G0900211Medical Research Council MR/N006364/1
6 · The paper itself

Abstract

The commensal yeast, Candida albicans, is an opportunistic pathogen in humans and forms filaments called hyphae and pseudohyphae, in which cell division requires precise temporal and spatial control to produce mononuclear cell compartments. High-frame-rate live-cell imaging (1 frame/min) revealed that nuclear division did not occur across the septal plane. We detected the presence of nucleolar fragments that may be extrachromosomal molecules carrying the ribosomal RNA genes. Cells occasionally maintained multiple nucleoli, suggesting either polyploidy, multiple nuclei and/or aneuploidy of ChrR., while the migration pattern of sister nuclei differed between unbranched and branched hyphae. The presented movie challenges and extends previous concepts of C. albicans cell division.

Indexed as

AneuploidyCandida albicansCell DivisionCell NucleolusCell NucleusCell Nucleus DivisionHumansHyphaePloidiesTime-Lapse ImagingVirulenceHyphaNuclear divisionSeptum

Identifiers

PMID26854071
PMCPMC4767323
OpenAlexW2295620334

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.