ArticleScientific reports2016
An integrative approach for analyzing hundreds of neurons in task performing mice using wide-field calcium imaging.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Kilohertz electrical stimulation evokes robust cellular responses like conventional frequencies but distinct population dynamics.Communications biology · 2025Article
- Beta-frequency sensory stimulation enhances gait rhythmicity through strengthened coupling between striatal networks and stepping movement.Nature communications · 2024Article
- Large-scale deep tissue voltage imaging with targeted-illumination confocal microscopy.Nature methods · 2024Article
- NeuroSeg-III: efficient neuron segmentation in two-photon CaBiomedical optics express · 2024Article
- Large-scale deep tissue voltage imaging with targeted illumination confocal microscopy.bioRxiv : the preprint server for biology · 2023Article
- Modulating cell signalling in vivo with magnetic nanotransducers.Nature reviews. Methods primers · 2022Article
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- Region-specific effects of ultrasound on individual neurons in the awake mammalian brain.iScience · 2021Article
- Extracting neuronal activity signals from microscopy recordings of contractile tissue using B-spline Explicit Active Surfaces (BEAS) cell tracking.Scientific reports · 2021Article
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- Real-time brain-wide multi-planar microscopy for simultaneous cortex and hippocampus imaging at the cellular resolution in mice.Biomedical optics express · 2021Article
- Decontaminate Traces From Fluorescence Calcium Imaging Videos Using Targeted Non-negative Matrix Factorization.Frontiers in neuroscience · 2021Article
- CaMKIIα-Positive Interneurons Identified via a microRNA-Based Viral Gene Targeting Strategy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Precision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicator.Neuron · 2020Article
- Remote scanning for ultra-large field of view in wide-field microscopy and full-field OCT.Biomedical optics express · 2020Article
- A Teensy microcontroller-based interface for optical imaging camera control during behavioral experiments.Journal of neuroscience methods · 2019Article
- Article
- Unique contributions of parvalbumin and cholinergic interneurons in organizing striatal networks during movement.Nature neuroscience · 2019Article
- Prediction of Forelimb Reach Results From Motor Cortex Activities Based on Calcium Imaging and Deep Learning.Frontiers in cellular neuroscience · 2019Article
- Mild Blast Injury Produces Acute Changes in Basal Intracellular Calcium Levels and Activity Patterns in Mouse Hippocampal Neurons.Journal of neurotrauma · 2018Article
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6 authors.
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Abstract
Advances in neurotechnology have been integral to the investigation of neural circuit function in systems neuroscience. Recent improvements in high performance fluorescent sensors and scientific CMOS cameras enables optical imaging of neural networks at a much larger scale. While exciting technical advances demonstrate the potential of this technique, further improvement in data acquisition and analysis, especially those that allow effective processing of increasingly larger datasets, would greatly promote the application of optical imaging in systems neuroscience. Here we demonstrate the ability of wide-field imaging to capture the concurrent dynamic activity from hundreds to thousands of neurons over millimeters of brain tissue in behaving mice. This system allows the visualization of morphological details at a higher spatial resolution than has been previously achieved using similar functional imaging modalities. To analyze the expansive data sets, we developed software to facilitate rapid downstream data processing. Using this system, we show that a large fraction of anatomically distinct hippocampal neurons respond to discrete environmental stimuli associated with classical conditioning, and that the observed temporal dynamics of transient calcium signals are sufficient for exploring certain spatiotemporal features of large neural networks.
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