ArticleScientific reports2016
Reactive oxygen species generated from skeletal muscles are required for gecko tail regeneration.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Article
- Reactive oxygen species drive wound epithelium and blastema formation in regenerating tail of Scincella tsinlingensis.Frontiers in zoology · 2026Article
- Glycyrrhiza uralensis crude water extract and licochalcone A and B to enhance chicken muscle satellite cell differentiation for cultured meat production.Scientific reports · 2025Article
- Autophagy mediated by ROS-AKT-FoxO pathway is required for intestinal regeneration in echinoderms.Cell communication and signaling : CCS · 2025Article
- Duox is the primary NADPH oxidase responsible for ROS production during adult caudal fin regeneration in zebrafish.iScience · 2023Article
- Live Imaging in Planarians: Immobilization and Real-Time Visualization of Reactive Oxygen Species.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Elevated pentose phosphate pathway flux supports appendage regeneration.Cell reports · 2022Article
- The Role of Oxidative Stress in Skeletal Muscle Myogenesis and Muscle Disease.Antioxidants (Basel, Switzerland) · 2022Review
- Post-amputation reactive oxygen species production is necessary for axolotls limb regeneration.Frontiers in cell and developmental biology · 2022Article
- Altered metabolic state impedes limb regeneration in salamanders.Zoological research · 2021Article
- Tissue Regeneration: The Dark Side of Opioids.International journal of molecular sciences · 2021Review
- Tails of reproduction: Regeneration leads to increased reproductive investment.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2021Article
- Reactive oxygen species during heart regeneration in zebrafish: Lessons for future clinical therapies.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2021Review
- Unlocking mammalian regeneration through hypoxia inducible factor one alpha signaling.Biomaterials · 2021Review
- Transcriptomic analysis of early stages of intestinal regeneration in Holothuria glaberrima.Scientific reports · 2021Article
- Salamander-like tail regeneration in the West African lungfish.Proceedings. Biological sciences · 2020Article
- Integrating Bioelectrical Currents and CaBioelectricity · 2020Review
- Amputation-induced reactive oxygen species signaling is required for axolotl tail regeneration.Developmental dynamics : an official publication of the American Association of Anatomists · 2019Article
- Weak magnetic fields alter stem cell-mediated growth.Science advances · 2019Article
- Ask1 and Akt act synergistically to promote ROS-dependent regeneration in Drosophila.PLoS genetics · 2019Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reactive oxygen species (ROS) participate in various physiological and pathological functions following generation from different types of cells. Here we explore ROS functions on spontaneous tail regeneration using gecko model. ROS were mainly produced in the skeletal muscle after tail amputation, showing a temporal increase as the regeneration proceeded. Inhibition of the ROS production influenced the formation of autophagy in the skeletal muscles, and as a consequence, the length of the regenerating tail. Transcriptome analysis has shown that NADPH oxidase (NOX2) and the subunits (p40(phox) and p47(phox)) are involved in the ROS production. ROS promoted the formation of autophagy through regulation of both ULK and MAPK activities. Our results suggest that ROS produced by skeletal muscles are required for the successful gecko tail regeneration.
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