ArticleChemical communications (Cambridge, England)2016
Comparison of design strategies for α-helix backbone modification in a protein tertiary fold.
Article in Chemical communications (Cambridge, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Interplay between CChembiochem : a European journal of chemical biology · 2025Article
- Backbone Modification in a Protein Hydrophobic Core.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Article
- Effects of altered backbone composition on the folding kinetics and mechanism of an ultrafast-folding protein.Chemical science · 2024Article
- Chemical Shifts of Artificial Monomers Used to Construct Heterogeneous-Backbone Protein Mimetics in Random Coil and Folded States.Peptide science (Hoboken, N.J.) · 2023Article
- Implications of the unfolded state in the folding energetics of heterogeneous-backbone protein mimetics.Chemical science · 2022Article
- Heterogeneous-Backbone Proteomimetic Analogues of Lasiocepsin, a Disulfide-Rich Antimicrobial Peptide with a Compact Tertiary Fold.ACS chemical biology · 2022Article
- Development of CHARMM Additive Potential Energy Parameters for α-Methyl Amino Acids.The journal of physical chemistry. B · 2021Article
- Vagabond: bond-based parametrization reduces overfitting for refinement of proteins.Acta crystallographica. Section D, Structural biology · 2021Article
- Analysis of folded structure and folding thermodynamics in heterogeneous-backbone proteomimetics.Methods in enzymology · 2021Review
- A twist in the road less traveled: The AMBER ff15ipq-m force field for protein mimetics.The Journal of chemical physics · 2020Article
- Incorporation of α-methylated amino acids into Apolipoprotein A-I mimetic peptides improves their helicity and cholesterol efflux potential.Biochemical and biophysical research communications · 2020Article
- Interplay of secondary and tertiary folding in abiotic foldamers.Chemical science · 2019Article
- Heterogeneous-Backbone Foldamer Mimics of a Computationally Designed, Disulfide-Rich Miniprotein.Chembiochem : a European journal of chemical biology · 2019Article
- Receptor selectivity from minimal backbone modification of a polypeptide agonist.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Differential Effects of βAngewandte Chemie (International ed. in English) · 2018Article
- Thermodynamic Scale of β-Amino Acid Residue Propensities for an α-Helix-like Conformation.Journal of the American Chemical Society · 2018Article
- Foldamer Tertiary Structure through Sequence-Guided Protein Backbone Alteration.Accounts of chemical research · 2018Article
- Advancing the Frontiers of Chemical Protein Synthesis-The 7Cell chemical biology · 2018Article
- Designing cooperatively folded abiotic uni- and multimolecular helix bundles.Nature chemistry · 2018Article
- Heterogeneous-Backbone Foldamer Mimics of Zinc Finger Tertiary Structure.Journal of the American Chemical Society · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
We report here the comparison of five classes of unnatural amino acid building blocks for their ability to be accommodated into an α-helix in a protein tertiary fold context. High-resolution structural characterization and analysis of folding thermodynamics yield new insights into the relationship between backbone composition and folding energetics in α-helix mimetics and suggest refined design rules for engineering the backbones of natural sequences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.