Evidence map›Paper›PMID 26853747›Full record

ArticleCell metabolism2016

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer.

Shawn M Davidson, Thales Papagiannakopoulos, Benjamin A Olenchock, Julia E Heyman, Mark A Keibler, Alba Luengo, Matthew R Bauer, Abhishek K Jha, James P O'Brien, Kerry A Pierce and 10 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 499 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
499citing papers in PubMed, 1 pooled it
37.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

499 citing papers in PubMed, 1 synthesis or guideline pooled it, 746 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Lung cancer metabolism: a dynamic and adaptive network.Cellular and molecular life sciences : CMLS · 2026
    Review
  4. Article
  5. Article
  6. Preliminary clinical investigation ofEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. A Stable Isotope Tracing Primer for the Mass Spectrometrist.Annual review of analytical chemistry (Palo Alto, Calif.) · 2026
    Review
  18. Article
  19. Article
  20. Review

439 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 1 country.

Shawn M DavidsonKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA.
Thales PapagiannakopoulosKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Benjamin A OlenchockKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Julia E HeymanKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Mark A KeiblerDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Alba LuengoKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Matthew R BauerKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Abhishek K JhaElucidata Corporation, Cambridge, MA 02139, USA.
James P O'BrienKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Kerry A PierceBroad Institute of MIT and Harvard University, Cambridge, MA 02142, USA.
Dan Y GuiKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Lucas B SullivanKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Thomas M WasylenkoDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Lakshmipriya SubbarajKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Christopher R ChinKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
Gregory StephanopolousDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Bryan T MottNational Center for Advancing Translational Sciences, NIH, Bethesda, MD 20892, USA.
Tyler JacksKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Clary B ClishBroad Institute of MIT and Harvard University, Cambridge, MA 02142, USA.
Matthew G Vander HeidenKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard University, Cambridge, MA 02142, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address: mvh@mit.edu.
Massachusetts Institute of Technology · USBroad Institute · USHarvard University · USNational Center for Advancing Translational Sciences · US

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Jacqueline A. Lees · 1985 to 2026
$93.9M
Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
PRE-DOCTORAL TRAINING IN THE BIOLOGICAL SCIENCEST32GM007287 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BELL, STEPHEN P., KEATING, AMY E · 1985 to 2019
$40.8M
Regulation of glucose metabolism to allow tumor initiation and growthR01CA168653 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI VANDER HEIDEN, MATTHEW G. · 2013 to 2019
$1.9M
Regulation of cellular metabolism by EglN dioxygenasesK08HL119355 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI OLENCHOCK, BENJAMIN A · 2013 to 2017
$746k
NCI NIH HHS P30 CA014051NCI NIH HHS P30CA1405141NCI NIH HHS R01 CA168653NCI NIH HHS R01CA168653NHLBI NIH HHS K08 HL119355NHLBI NIH HHS K08HL119355NIGMS NIH HHS T32 GM007287NIGMS NIH HHS T32GM007287NIGMS NIH HHS T32 GM007753NIGMS NIH HHS T32GM007753
6 · The paper itself

Abstract

Cultured cells convert glucose to lactate, and glutamine is the major source of tricarboxylic acid (TCA)-cycle carbon, but whether the same metabolic phenotype is found in tumors is less studied. We infused mice with lung cancers with isotope-labeled glucose or glutamine and compared the fate of these nutrients in tumor and normal tissue. As expected, lung tumors exhibit increased lactate production from glucose. However, glutamine utilization by both lung tumors and normal lung was minimal, with lung tumors showing increased glucose contribution to the TCA cycle relative to normal lung tissue. Deletion of enzymes involved in glucose oxidation demonstrates that glucose carbon contribution to the TCA cycle is required for tumor formation. These data suggest that understanding nutrient utilization by tumors can predict metabolic dependencies of cancers in vivo. Furthermore, these data argue that the in vivo environment is an important determinant of the metabolic phenotype of cancer cells.

Indexed as

Tumor MicroenvironmentAnimalsBlood GlucoseCarcinoma, Non-Small-Cell LungCell Line, TumorGlucoseHumansLungLung NeoplasmsMice, 129 StrainMice, Inbred C57BLMice, NudeMitochondriaMutation, MissenseNeoplasm TransplantationProto-Oncogene Proteins p21(ras)Blood GlucoseGlucoseKRAS protein, humanProto-Oncogene Proteins p21(ras)Pyruvic Acid

Identifiers

PMID26853747
PMCPMC4785096
OpenAlexW2264411128

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.