Evidence map›Paper›PMID 26853710›Full record

ArticleMayo Clinic proceedings2016

Childhood Attention-Deficit/Hyperactivity Disorder, Sex, and Obesity: A Longitudinal Population-Based Study.

Roxana L Aguirre Castaneda, Seema Kumar, Robert G Voigt, Cynthia L Leibson, William J Barbaresi, Amy L Weaver, Jill M Killian, Slavica K Katusic

Abstract readComparative Study
In one paragraph

Article in Mayo Clinic proceedings, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Roxana L Aguirre CastanedaDivision of Pediatric Endocrinology and Metabolism, University of Illinois College of Medicine at Peoria, Peoria.
Seema KumarDivision of Pediatric Endocrinology and Metabolism, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN. Electronic address: kumar.seema@mayo.edu.
Robert G VoigtDepartment of Pediatrics, Texas Children's Hospital, Baylor College of Medicine, Houston.
Cynthia L LeibsonDivision of Epidemiology, Mayo Clinic, Rochester, MN.
William J BarbaresiDivision of Developmental Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA.
Amy L WeaverDivision of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN.
Jill M KillianDivision of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN.
Slavica K KatusicDivision of Epidemiology, Mayo Clinic, Rochester, MN.
Mayo Clinic in Florida · USMayo Clinic in Arizona · USBoston Children's Hospital · USTexas Children's Hospital · USUniversity of Illinois Urbana-Champaign · US

Funding

Rochester Epidemiology ProjectR01AG034676 · NIA · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A, ST SAUVER, JENNIFER LYNN · 2010 to 2019
$9.5M
ROCHESTER EPIDEMIOLOGY PROJECTR01AR030582 · NIAMS · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A · 1986 to 2009
$5.1M
EPIDEMIOLOGY OF LEARNING DISABILITYR01HD029745 · NICHD · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · PI KATUSIC, SLAVICA K · 1995 to 1998
–
NIAMS NIH HHS AR 30582NIAMS NIH HHS R01 AR030582NIA NIH HHS R01 AG034676NIA NIH HHS R01-AG034676NICHD NIH HHS HD29745NICHD NIH HHS R01 HD029745
6 · The paper itself

Abstract

objectiveTo assess obesity rates during childhood and young adulthood in patients with attention-deficit/hyperactivity disorder (ADHD) and age- and sex-matched controls derived from a population-based birth cohort because cross-sectional studies suggest an association between ADHD and obesity. PATIENTS AND

methodsStudy subjects included patients with childhood ADHD (n=336) and age- and sex-matched non-ADHD controls (n=665) from a 1976 to 1982 birth cohort (N=5718). Height, weight, and stimulant treatment measurements were abstracted retrospectively from medical records documenting care provided from January 1, 1976, through August 31, 2010. The association between ADHD and obesity in patients with ADHD relative to controls was estimated using Cox models.

resultsPatients with attention-deficit/hyperactivity disorder were 1.23 (95% CI, 1.00-1.50; P<.05) times more likely to be obese during the follow-up period than were non-ADHD controls. This association was not statistically significant in either sex (female participants: hazard ratio [HR], 1.49; 95% CI, 0.98-2.27; P=.06; male participants HR, 1.17, 95% CI, 0.92-1.48; P=.20). Patients with ADHD who were not obese as of the date ADHD research diagnostic criteria were met were 1.56 (95% CI, 1.14-2.13; P<.01) times more likely to be obese during the subsequent follow-up than were controls. This association was statistically significant in female study subjects (HR, 2.02; 95% CI, 1.13-3.60; P=.02), but not in male participants (HR, 1.41; 95% CI, 0.97-2.05; P=.07). A higher proportion of patients with ADHD were obese after the age of 20 years compared with non-ADHD controls (34.4% vs 25.1%; P=.01); this difference was observed only in female patients (41.6% vs 19.2%). There were no differences in obesity rates between stimulant-treated and nontreated patients with ADHD.

conclusionChildhood ADHD is associated with obesity during childhood and young adulthood in females. Treatment with stimulant medications is not associated with the development of obesity up to young adulthood.

Indexed as

AdolescentAge FactorsAttention Deficit Disorder with HyperactivityChildChild, PreschoolCohort StudiesCross-Sectional StudiesFemaleHumansLongitudinal StudiesMaleMinnesotaObesityPopulation SurveillanceRetrospective StudiesSex Factors

Identifiers

PMID26853710
PMCPMC5264451
OpenAlexW2271173963

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.