Evidence map›Paper›PMID 26853708›Full record

ArticleContrast media & molecular imaging2016

Cationic gadolinium chelate for magnetic resonance imaging of cartilaginous defects.

Kido Nwe, Ching-Hui Huang, Feini Qu, Robert Warden-Rothman, Clare Y Zhang, Robert L Mauck, Andrew Tsourkas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Contrast media & molecular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kido NweDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Ching-Hui HuangDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Feini QuDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Robert Warden-RothmanDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Clare Y ZhangDepartment of Radiology, Coatesville Veterans Affairs Medical Center, Coatesville, PA, USA.
Robert L MauckDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
Andrew TsourkasDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.

Funding

Highly Paramagnetic, Biodegradable Nanoclusters for Imaging Prostate CancerR01CA157766 · NCI · UNIVERSITY OF PENNSYLVANIA · PI TSOURKAS, ANDREW · 2011 to 2015
$1.6M
Imaging B Cells with Gd-Labeled Dendrimer NanoclustersR01EB012065 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI TSOURKAS, ANDREW · 2010 to 2013
$1.4M
Engineered Multi-Functional Nanofibrous Meniscus ImplantsI01RX000174 · VA · PHILADELPHIA VA MEDICAL CENTER · PI ESTERHAI, JOHN, MAUCK, ROBERT L · 2009 to 2018
–
NCI NIH HHS R01 CA157766NIBIB NIH HHS R01 EB012065RRD VA I01 RX000174
6 · The paper itself

Abstract

The ability to detect meniscus defects by magnetic resonance arthrography (MRA) can be highly variable. To improve the delineation of fine tears, we synthesized a cationic gadolinium complex, (Gd-DOTA-AM4 )(2+) , that can electrostatically interact with Glycosaminoglycans (GAGs). The complex has a longitudinal relaxivity (r1) of 4.2 mM(-1) s(-1) and is highly stable in serum. Its efficacy in highlighting soft tissue tears was evaluated in comparison to a clinically employed contrast agent (Magnevist) using explants obtained from adult bovine menisci. In all cases, Gd-DOTA-AM4 appeared to improve the ability to detect the soft tissue defect by providing increased signal intensity along the length of the tear. Magnevist shows a strong signal near the liquid-meniscus interface, but much less contrast is observed within the defect at greater depths. This provides initial evidence that cationic contrast agents can be used to improve the diagnostic accuracy of MRA. Copyright © 2016 John Wiley & Sons, Ltd.

Indexed as

GadoliniumAnimalsCartilageCationsCattleChelating AgentsGlycosaminoglycansHeterocyclic CompoundsMagnetic Resonance ImagingOrganometallic CompoundsWounds and InjuriesCationsChelating AgentsGadoliniumgadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetateGlycosaminoglycansHeterocyclic CompoundsOrganometallic CompoundscationicchelateDOTAgadoliniumimagingmagenevistmagnetic resonance arthrographyMRA

Identifiers

PMID26853708
PMCPMC4892988

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.