Evidence map›Paper›PMID 26853557›Full record

ReviewExercise immunology review

Exercise, inflammation, and fatigue in cancer survivors.

Emily C P LaVoy, Christopher P Fagundes, Robert Dantzer

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC
In one paragraph

Review in Exercise immunology review. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05067777 (Massage for Prostate Cancer-Related Fatigue), which is not on this map. Cited by 73 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 10 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05067777 phase2terminatednot on this map

Massage for Prostate Cancer-Related Fatigue (mPROSTATE)

TypeinterventionalSponsorUniversity of UtahRan2022 to 2025Enrolled28ConditionsProstate CarcinomaArmsSwedish Massage Therapy (SMT), Light Touch (LT) Control, Waitlist Control (WLC)
3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 10 syntheses or guidelines pooled it, 138 citations in OpenAlex.

  1. Pooled it
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  3. Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Pooled it
  4. Yoga for fatigue in people with cancer.The Cochrane database of systematic reviews · 2025
    Pooled it
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  9. Interventions for multidimensional aspects of breast cancer-related fatigue: a meta-analytic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
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  15. The Health Promoting Mindfulness or Qigong Educational Programs for Beneficial Lifestyle Changes of Cancer Survivors.Journal of cancer education : the official journal of the American Association for Cancer Education · 2020
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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Emily C P LaVoyLaboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, Houston, TX, USA.
Christopher P FagundesDepartment of Health Disparities Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Symptom Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX..
Robert DantzerDepartment of Symptom Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX.
University of Houston · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Kathrin Milbury · 1985 to 2026
$290.8M
Neuroimmune Mechanisms of Recovery from Comorbid Depression and Chronic PainR01NS073939 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DANTZER, ROBERT, HEIJNEN, COBI J · 2011 to 2020
$4.0M
The Metabolic Basis of Cancer-Related FatigueR01CA193522 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DANTZER, ROBERT · 2015 to 2023
$3.8M
A novel molecular switch regulating transition from acute to chronic pain.R01NS074999 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KAVELAARS, ANNEMIEKE · 2011 to 2015
$1.7M
Blood-Brain Barrier Transport Mechanisms in Inflammation-Induced DepressionR21MH104694 · NIMH · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DANTZER, ROBERT · 2015 to 2016
$444k
Targeting Neural Mitochondria to Treat Chemotherapy-Induced Peripheral NeuropathyR21CA183736 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DANTZER, ROBERT, HEIJNEN, COBI J · 2014 to 2015
$383k
NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA193522NCI NIH HHS R21 CA183736NIMH NIH HHS R21 MH104694NINDS NIH HHS R01 NS073939NINDS NIH HHS R01 NS074999
6 · The paper itself

Abstract

Cancer-related fatigue significantly disrupts normal functioning and quality of life for a substantial portion of cancer survivors, and may persist for years following cancer treatment. While the causes of persistent fatigue among cancer survivors are not yet fully understood, accumulating evidence suggests that several pathways, including chronic inflammation, autonomic imbalance, HPA-axis dysfunction, and/or mitochondrial damage, could contribute towards the disruption of normal neuronal function and result in the symptom of cancer-related fatigue. Exercise training interventions have been shown to be some of the more successful treatment options to address cancer-related fatigue. In this review, we discuss the literature regarding the causes of persistent fatigue in cancer survivors and the mechanisms by which exercise may relieve this symptom. There is still much work to be done until the prescription of exercise becomes standard practice for cancer survivors. With improvements in the quality of studies, evidenced-based exercise interventions will allow exercise scientists and oncologists to work together to treat cancer-related fatigue.

Indexed as

ExerciseCancer SurvivorsHumansInflammationNeoplasmsQuality of LifeSurvivorsCancerExerciseFatigueInflammationPhysical Activity

Identifiers

PMID26853557
PMCPMC4755327
OpenAlexW2258317460

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.