ArticleAlcoholism, clinical and experimental research2016
Associations Between Recent Heavy Drinking and Dorsal Anterior Cingulate N-Acetylaspartate and Glutamate Concentrations in Non-Treatment-Seeking Individuals with Alcohol Dependence.
Article in Alcoholism, clinical and experimental research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03220776 (Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics
Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- Effects of Gabapentin on Dorsal Anterior Cingulate Cortex GABA and Glutamate Levels and Their Associations With Abstinence in Alcohol Use Disorder: A Randomized Clinical Trial.The American journal of psychiatry · 2021Trial
- Probing the neurochemical mechanisms of rTMS for alcohol use disorder: Results from a randomized, sham-controlled, double-blind, crossover, proton MR Spectroscopy study.Molecular psychiatry · 2026Article
- AlteredeNeuro · 2026Article
- AlteredbioRxiv : the preprint server for biology · 2025Article
- Brain glutathione levels and associations with recent drinking in treatment-naïve individuals with alcohol use disorder versus light drinkers.Drug and alcohol dependence · 2025Article
- The neurobehavioural effects of cannabidiol in alcohol use disorder: Study protocol for a double-blind, randomised, cross over, placebo-controlled trial.Contemporary clinical trials communications · 2024Article
- Imaging neuroinflammation in individuals with substance use disorders.The Journal of clinical investigation · 2024Review
- Differential Effects of Chronic Ethanol Use on Mouse Neuronal and Astroglial Metabolic Activity.Neurochemical research · 2023Article
- Neuroimaging in alcohol use disorder: From mouse to man.Journal of neuroscience research · 2022Review
- Anterior cingulate cortex metabolites and white matter microstructure: a multimodal study of emergent alcohol use disorder.Brain imaging and behavior · 2021Article
- GABAergic dysfunction, neural network hyperactivity and memory impairments in human aging and Alzheimer's disease.Seminars in cell & developmental biology · 2021Review
- Effects of ceftriaxone on ethanol drinking and GLT-1 expression in ethanol dependence and relapse drinking.Alcohol (Fayetteville, N.Y.) · 2021Article
- Intraindividual changes in brain GABA, glutamate, and glutamine during monitored abstinence from alcohol in treatment-naive individuals with alcohol use disorder.Addiction biology · 2020Article
- Alcohol Use Disorder, Neurodegeneration, Alzheimer's and Parkinson's Disease: Interplay Between Oxidative Stress, Neuroimmune Response and Excitotoxicity.Frontiers in cellular neuroscience · 2020Review
- Signatures of alcohol use in the structure and neurochemistry of insular cortex: a correlational study.Psychopharmacology · 2019Article
- Evidence for a unique association between fronto-cortical glycine levels and recent heavy drinking in treatment naïve individuals with alcohol use disorder.Neuroscience letters · 2019Article
- Brain Glutamate, GABA, and Glutamine Levels and Associations with Recent Drinking in Treatment-Naïve Individuals with Alcohol Use Disorder Versus Light Drinkers.Alcoholism, clinical and experimental research · 2019Article
- Cerebral Metabolites on the Descending Limb of Acute Alcohol: A Preliminary 1H MRS Study.Alcohol and alcoholism (Oxford, Oxfordshire) · 2019Article
- N-acetyl cysteine in the treatment of alcohol use disorder in patients with liver disease: Rationale for further research.Expert opinion on investigational drugs · 2018Review
- Effects of Alcohol Cues on MRS Glutamate Levels in the Anterior Cingulate.Alcohol and alcoholism (Oxford, Oxfordshire) · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundProton magnetic resonance spectroscopy ((1) H-MRS) studies have consistently found abnormal brain concentrations of N-acetylaspartate (NAA) and glutamate in individuals with alcohol use disorders (AUD) relative to light drinkers. However, most such studies have focused on individuals in treatment for severe alcohol dependence (AD), and few studies have investigated associations between neurochemical concentrations and recent alcohol consumption. This study focused on associations between recent drinking and prefrontal neurometabolite concentrations in nonsevere, non-treatment-seeking individuals with AUD.
methodsNineteen treatment-naïve alcohol-dependent individuals aged 21 to 40 completed a (1) H-MRS scan. Single-voxel (1) H-MRS spectra were acquired in dorsal anterior cingulate cortex (dACC) using a 2-dimensional J-resolved point resolved spectroscopy sequence. Associations between recent heavy drinking, assessed using the Timeline FollowBack, and dACC metabolite concentrations were estimated via regression controlling for within-voxel tissue composition.
resultsParticipants provided a negative breathalyzer reading and reported between 1 and 5 days (M = 2.45, SD = 1.23) since their last drink. Number of heavy drinking days in the 14 days preceding the scan (M = 4.84, SD = 3.32) was significantly inversely associated with both glutamate/water (β = -0.63, t(17) = -3.37, p = 0.004) and NAA/water concentrations (β = -0.59, t(17) = -2.98, p = 0.008).
conclusionsThis study extends the literature by demonstrating inverse associations between recent heavy drinking and dACC glutamate and NAA concentrations in a sample of nonsevere, non-treatment-seeking individuals with AD. These findings may support the hypothesis that amount of recent alcohol consumption may account for differences in neuronal metabolism, even in nonsevere, non-treatment-seeking alcoholics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.