ArticleCurrent biology : CB2016
Interface Contractility between Differently Fated Cells Drives Cell Elimination and Cyst Formation.
Article in Current biology : CB, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
70 citing papers in PubMed, 146 citations in OpenAlex.
- Wnt signaling regulates passive cell competition in the retina by inducing differential cell adhesion.Nature communications · 2026Article
- Toll receptors mediate tissue intrinsic surveillance against aberrant cells by detecting cell fate aberrations.Development (Cambridge, England) · 2026Article
- Physical traits of supercompetitors in cell competition.Journal of the Royal Society, Interface · 2025Article
- RhoGEF2 overexpression induces cell competition dependent on Ptp10D, Crumbs and the Hippo signaling pathway.Journal of cell science · 2025Article
- Mechanical control of cell fate decisions in the skin epidermis.Nature communications · 2025Article
- Supracellular actomyosin assemblies: master coordinators of development.Development (Cambridge, England) · 2025Review
- Elimination of cells with local mismatch in differentiation timing contributes to synchronize tissue development.iScience · 2025Article
- The cell-adhesion molecule Echinoid promotes tissue survival and separately restricts tissue overgrowth.Development (Cambridge, England) · 2025Article
- Soft matter mechanics of immune cell aggregates.Journal of the Royal Society, Interface · 2025Article
- Force transmission is a master regulator of mechanical cell competition.Nature materials · 2025Article
- Epithelial cell-fate switch triggering ectopic ligand-receptor-mediated JAK-STAT signaling promotes tumorigenesis iniScience · 2025Article
- Mathematical modeling of evolution of cell networks in epithelial tissues.Quantitative biology (Beijing, China) · 2024Article
- Patterned apoptosis has an instructive role for local growth and tissue shape regulation in a fast-growing epithelium.Current biology : CB · 2024Article
- Mechanical control of neural plate folding by apical domain alteration.Nature communications · 2023Article
- From cells to form: A roadmap to study shape emergence in vivo.Biophysical journal · 2023Review
- Elimination of aberrantly specified cell clones is independent of interfacial Myosin II accumulation.Journal of cell science · 2023Article
- Homophilic interaction of cell adhesion molecule 3 coordinates retina neuroepithelial cell proliferation.The Journal of cell biology · 2023Article
- Engineering tools for quantifying and manipulating forces in epithelia.Biophysics reviews · 2023Review
- Bilateral JNK activation is a hallmark of interface surveillance and promotes elimination of aberrant cells.eLife · 2023Article
- Homeotic compartment curvature and tension control spatiotemporal folding dynamics.Nature communications · 2023Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Although cellular tumor-suppression mechanisms are widely studied, little is known about mechanisms that act at the level of tissues to suppress the occurrence of aberrant cells in epithelia. We find that ectopic expression of transcription factors that specify cell fates causes abnormal epithelial cysts in Drosophila imaginal discs. Cysts do not form cell autonomously but result from the juxtaposition of two cell populations with divergent fates. Juxtaposition of wild-type and aberrantly specified cells induces enrichment of actomyosin at their entire shared interface, both at adherens junctions as well as along basolateral interfaces. Experimental validation of 3D vertex model simulations demonstrates that enhanced interface contractility is sufficient to explain many morphogenetic behaviors, which depend on cell cluster size. These range from cyst formation by intermediate-sized clusters to segregation of large cell populations by formation of smooth boundaries or apical constriction in small groups of cells. In addition, we find that single cells experiencing lateral interface contractility are eliminated from tissues by apoptosis. Cysts, which disrupt epithelial continuity, form when elimination of single, aberrantly specified cells fails and cells proliferate to intermediate cell cluster sizes. Thus, increased interface contractility functions as error correction mechanism eliminating single aberrant cells from tissues, but failure leads to the formation of large, potentially disease-promoting cysts. Our results provide a novel perspective on morphogenetic mechanisms, which arise from cell-fate heterogeneities within tissues and maintain or disrupt epithelial homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.