ArticleScientific reports2016
Light adaptation does not prevent early retinal abnormalities in diabetic rats.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 14 citations in OpenAlex.
- Explaining Retinal Susceptibility to Diabetes Through Photoreceptor Biology.International journal of molecular sciences · 2026Review
- Visual Dysfunction in Diabetes.Annual review of vision science · 2023Review
- Photoreceptor cells and RPE contribute to the development of diabetic retinopathy.Progress in retinal and eye research · 2021Review
- Diabetic photoreceptors: Mechanisms underlying changes in structure and function.Visual neuroscience · 2020Review
- The effects of early diabetes on inner retinal neurons.Visual neuroscience · 2020Article
- Photoreceptor responses to light in the pathogenesis of diabetic retinopathy.Visual neuroscience · 2020Review
- Light deprivation reduces the severity of experimental diabetic retinopathy.Neurobiology of disease · 2020Article
- Transducin1, Phototransduction and the Development of Early Diabetic Retinopathy.Investigative ophthalmology & visual science · 2019Article
- Müller glial dysfunction during diabetic retinopathy in rats is reduced by the acrolein-scavenging drug, 2-hydrazino-4,6-dimethylpyrimidine.Diabetologia · 2018Article
- Can allopurinol improve retinopathy in diabetic rats? Oxidative stress or uric acid; which one is the culprit?Research in pharmaceutical sciences · 2017Article
- Do photoreceptor cells cause the development of retinal vascular disease?Vision research · 2017Review
- Nogo receptor knockdown and ciliary neurotrophic factor attenuate diabetic retinopathy in streptozotocin-induced diabetic rats.Molecular medicine reports · 2017Article
- Loss of CD40 attenuates experimental diabetes-induced retinal inflammation but does not protect mice from electroretinogram defects.Visual neuroscience · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The aetiology of diabetic retinopathy (DR), the leading cause of blindness in the developed world, remains controversial. One hypothesis holds that retinal hypoxia, exacerbated by the high O2 consumption of rod photoreceptors in the dark, is a primary cause of DR. Based on this prediction we investigated whether early retinal abnormalities in streptozotocin-induced diabetic rats are alleviated by preventing the rods from dark adapting. Diabetic rats and their non-diabetic littermates were housed in a 12:12 hour light-dim light photocycle (30 lux during the day and 3 lux at night). Progression of early retinal abnormalities in diabetic rats was assessed by monitoring the ERG b-wave and oscillatory potentials, Müller cell reactive gliosis, and neuronal cell death, as assayed by TUNEL staining and retinal thickness at 6 and 12 weeks after diabetes induction. Maintaining diabetic animals in a dim-adapting light did not slow the progression of these neuronal and glial changes when compared to diabetic rats maintained in a standard 12:12 hour light-dark photocycle (30 lux during the day and 0 lux at night). Our results indicate that neuronal and glial abnormalities in early stages of diabetes are not exacerbated by rod photoreceptor O2 consumption in the dark.
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