ArticleInternational journal of experimental pathology2015
Characterization of lesion formation in marmosets following inhalational challenge with different strains of Burkholderia pseudomallei.
Article in International journal of experimental pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Rapidly Progressing Melioidosis Outbreak in City Center Zoo, Hong Kong, 2024.Emerging infectious diseases · 2025Article
- Development of a System to Deliver Inhalational Antibiotics to Marmosets.Antibiotics (Basel, Switzerland) · 2025Article
- Review
- Marmosets as models of infectious diseases.Frontiers in cellular and infection microbiology · 2024Review
- Efficacy of Co-Trimoxazole against Experimental Melioidosis Acquired by Different Routes of Infection.Antimicrobial agents and chemotherapy · 2022Article
- The Innate Immune Response in the Marmoset during the Acute Pneumonic Disease Caused by Burkholderia pseudomallei.Infection and immunity · 2022Article
- Review
- The lymphatic system as a potential mechanism of spread of melioidosis following ingestion of Burkholderia pseudomallei.PLoS neglected tropical diseases · 2021Article
- Comparative virulence of three different strains of Burkholderia pseudomallei in an aerosol non-human primate model.PLoS neglected tropical diseases · 2021Article
- Evaluation of four sampling devices for Burkholderia pseudomallei laboratory aerosol studies.PLoS neglected tropical diseases · 2021Article
- Dose-dependant acute or subacute disease caused by Burkholderia pseudomallei strain NCTC 13392 in a BALB/c aerosol model of infection.Journal of applied microbiology · 2019Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The marmoset model of melioidosis was used to explore whether there was any difference in the disease presentation and/or the lesion formation following inhalational challenge with one of four strains of Burkholderia pseudomallei (K96243, 1026b, HBPUB10303a and HBPUB10134a). Marmosets were challenged with a range of bacterial doses and bacterial load, histological and physiological features were determined temporally following lethal disease. Melioidosis presented as an acute, febrile disease with bacteraemia, bacterial dissemination, necrotizing hepatitis, splenitis and pneumonia which was independent of the challenge strain. Generally, there were no major differences in the manifestation of melioidosis following challenge by the different strains of B. pseudomallei; however, there were some differences in the time to death and the severity of the pathological features. The pathological features observed in the liver and spleen of animals challenged with B. pseudomallei strain 1026b were statistically less severe (P < 0.05) and less frequent. However, more severe foci of disease were evident in the lungs of animals challenged with strain 1026b. In all cases, the lesions developed from small areas of bacteria-infected macrophages surrounded by non-infected neutrophils into large lesions with both immune cell types infected. The marmoset model was a useful tool enabling the distinction of subtle difference in the pathological response to B. pseudomallei.
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