Evidence map›Paper›PMID 26852655›Full record

ArticleBlood cells, molecules & diseases2016

Genome-wide association study of serum iron phenotypes in premenopausal women of European descent.

Daniel L Koller, Erik A Imel, Dongbing Lai, Leah R Padgett, Dena Acton, Amie Gray, Munro Peacock, Michael J Econs, Tatiana Foroud

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood cells, molecules & diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Daniel L KollerDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA. Electronic address: dkoller@iu.edu.
Erik A ImelDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Dongbing LaiDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Leah R PadgettDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Dena ActonDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Amie GrayDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Munro PeacockDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Michael J EconsDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Tatiana ForoudDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Indiana University – Purdue University Indianapolis · USIndiana University School of Medicine

Funding

ZOSUQUIDAR TRIHYDROCHLORIDE DURING CONVENTIONAL INDUCTION AND POST-REMISSIONM01RR000750 · NCRR · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI RODRIGUEZ, HENRY · 1985 to 2008
$25.5M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
GENETICS OF BONE LOSS AND BONE STRENGTH IN WOMEN &MENP01AG018397 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI ECONS, MICHAEL J · 2000 to 2010
$19.1M
Identification of genes that affect peak BMD in men and womenR01AG041517 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI ECONS, MICHAEL J · 2011 to 2015
$2.9M
FGF23 in Pediatric Phosphate Physiology and X-linked Hypophosphatemic Rickets.K23AR057096 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI IMEL, ERIK ALLEN · 2009 to 2013
$642k
The Effects of Iron Status on FGF23 Metabolism and Bone Health.R21AR061078 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI ECONS, MICHAEL J · 2011 to 2012
$381k
NCATS NIH HHS UL1 TR001108NCRR NIH HHS M01 RR000750NCRR NIH HHS M01 RR-00750NHGRI NIH HHS HHSN268200782096CNHLBI NIH HHS HHSN268200782096CNIAMS NIH HHS K23 AR057096NIAMS NIH HHS K23AR057096NIAMS NIH HHS R21 AR061078NIA NIH HHS P01 AG018397NIA NIH HHS P01 AG-18397NIA NIH HHS R01 AG041517
6 · The paper itself

Abstract

A genome-wide association study was performed on 1130 premenopausal women to detect common variants associated with three serum iron-related phenotypes. Total iron binding capacity was strongly associated (p=10(-14)) with variants in and near the TF gene (transferrin), the serum iron transporting protein, and with variants in HFE (p=4×10(-7)), which encodes the human hemochromatosis gene. Association was also detected between percent iron saturation (p=10(-8)) and variants in the chromosome 6 region containing both HFE and SLC17A2, which encodes a phosphate transport protein. No significant associations were detected with serum iron, but variants in HFE were suggestive (p=10(-6)). Our results corroborate prior studies in older subjects and demonstrate that the association of these genetic variants with iron phenotypes can be detected in premenopausal women.

Indexed as

AdultChromosomes, Human, Pair 6FemaleGene ExpressionGenome-Wide Association StudyHemochromatosisHemochromatosis ProteinHistocompatibility Antigens Class IHumansIronMembrane ProteinsMiddle AgedPhenotypePolymorphism, GeneticPremenopauseSequence Analysis, DNAHemochromatosis ProteinHFE protein, humanHistocompatibility Antigens Class IIronMembrane ProteinsSLC17A2 protein, humanSodium-Phosphate Cotransporter Proteins, Type ITransferrinGWASHemochromatosisIronPremenopausalTransferrin

Identifiers

PMID26852655
PMCPMC4746500
OpenAlexW2192243354

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.