ArticleAging2016
Hexokinase is a key regulator of energy metabolism and ROS activity in insect lifespan extension.
Article in Aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 80 citations in OpenAlex.
- Contrasting Starvation Strategies in Congeneric Pentatomids: A Predator (Arma chinensis) Versus a Pest (Halyomorpha halys).Archives of insect biochemistry and physiology · 2026Article
- Transition From Land to Sea: Comparative Genomics Illuminates the Adaptive Evolution of the Intertidal Spider.Molecular ecology resources · 2026Article
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- Growth Phase-Dependent Changes in the Carbohydrate Metabolism of Penicillium Strains from Diverse Temperature Classes in Response to Cold Stress.International journal of molecular sciences · 2025Article
- The transcriptome reveals the potential mechanism of 20E terminating diapause in cotton bollworm, Helicoverpa armigera.BMC genomics · 2025Article
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- Energy Reserve Allocation in the Trade-Off between Migration and Reproduction in Fall Armyworm.Insects · 2024Article
- Diapause-like Drug-Tolerant Persister State: The Key to Nirvana Rebirth.Medicina (Kaunas, Lithuania) · 2024Review
- A Study on the Effect of Energy on the Development of Silkworm Embryos Using an Estrogen-Related Receptor.International journal of molecular sciences · 2023Article
- Mmp-induced fat body cell dissociation promotes pupal development and moderately averts pupal diapause by activating lipid metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Timing of Diapause Initiation and Overwintering Conditions Alter Gene Expression Profiles inFrontiers in physiology · 2022Article
- Hexokinase Is Required for Sex Pheromone Biosynthesis inInsects · 2021Article
- Peroxiredoxin alleviates the fitness costs of imidacloprid resistance in an insect pest of rice.PLoS biology · 2021Article
- High-throughput profiling of diapause regulated genes from Trichogramma dendrolimi (Hymenoptera: Trichogrammatidae).BMC genomics · 2020Article
- Genomic Signature of Shifts in Selection in a Subalpine Ant and Its Physiological Adaptations.Molecular biology and evolution · 2020Article
- Special Significance of Non-Frontiers in cell and developmental biology · 2020Review
- Transcriptome Sequencing Reveals Potential Mechanisms of the Maternal Effect on Egg Diapause Induction ofInternational journal of molecular sciences · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Developmental arrest (diapause) is a 'non-aging' state that is similar to the Caenorhabditis elegans dauer stage and Drosophila lifespan extension. Diapause results in low metabolic activity and a profound extension of insect lifespan. Here, we cloned the Helicoverpa armigera Hexokinase (HK) gene, a gene that is critical for the developmental arrest of this species. HK expression and activity levels were significantly increased in nondiapause-destined pupae compared with those of diapause-destined pupae. Downregulation of HK activity reduced cell viability and delayed pupal development by reducing metabolic activity and increasing ROS activity, which suggests that HK is a key regulator of insect development. We then identified the transcription factors Har-CREB, -c-Myc, and -POU as specifically binding the Har-HK promoter and regulating its activity. Intriguingly, Har-POU and -c-Myc are specific transcription factors for HK expression, whereas Har-CREB is nonspecific. Furthermore, Har-POU and -c-Myc could respond to ecdysone, which is an upstream hormone. Therefore, low ecdysone levels in diapause-destined individuals lead to low Har-POU and -c-Myc expression levels, ultimately repressing Har-HK expression and inducing entry into diapause or lifespan extension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.