ArticleInternational journal of hygiene and environmental health2016
Urinary and blood cadmium and lead and kidney function: NHANES 2007-2012.
Article in International journal of hygiene and environmental health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
63 citing papers in PubMed, 3 syntheses or guidelines pooled it, 189 citations in OpenAlex.
- Blood Lead Level and Renal Impairment among Adults: A Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Toxic Metals and Chronic Kidney Disease: a Systematic Review of Recent Literature.Current environmental health reports · 2018Pooled it
- Environmental exposures and pediatric kidney function and disease: A systematic review.Environmental research · 2017Pooled it
- Environmental exposures and pediatric kidney health.Pediatric research · 2026Review
- Estimating the Global Burden and Health Risks Associated with Dietary and Cigarette-Related Cadmium Exposure.Biological trace element research · 2026Article
- Urinary heavy metal and trace element mixtures in chronic kidney disease: associations and implications for potential reverse causality.Frontiers in toxicology · 2026Article
- Modeling kidney fibrosis and tubular regeneration in iPSC-derived kidney organoids.Stem cell research & therapy · 2025Article
- Association of metal and metalloid exposure with cardiovascular-kidney-metabolic syndrome: mediation by inflammation, oxidative stress, and aging.BMC public health · 2025Article
- Multiple metal exposure and renal tubular damage of residents in a metal-polluted region in Korea.Environmental analysis, health and toxicology · 2025Article
- Association between blood cadmium levels and the risk of chronic kidney disease in Korea, based on the Korea National Health and Nutrition Examination Survey 2016-2017.Asian biomedicine : research, reviews and news · 2025Article
- A Comparative Study on the Paradoxical Relationship Between Heavy Metal Exposure and Kidney Function.Diagnostics (Basel, Switzerland) · 2025Article
- Review
- Cadmium and its inorganic compounds - Addendum: re-evaluation of the BLW: Assessment Values in Biological Material - Translation of the German version from 2025.The MAK collection for occupational health and safety · 2025Review
- Is Chronic Kidney Disease Due to Cadmium Exposure Inevitable and Can It Be Reversed?Biomedicines · 2024Review
- Exposure to cadmium and lead is associated with diabetic kidney disease in diabetic patients.Environmental health : a global access science source · 2024Article
- Is Kidney Stone Associated with Thyroid Disease? The United States National Health and Nutrition Examination Survey 2007-2018.Endocrine, metabolic & immune disorders drug targets · 2024Article
- Exposure to low levels of heavy metals and chronic kidney disease in the US population: A cross sectional study.PloS one · 2024Article
- Relationships between blood concentrations of cadmium, lead, mercury, selenium, and manganese and the risk of chronic kidney disease: a cross-sectional study based on NHANES 2011-2018.Archives of medical science : AMS · 2024Article
- Nutraceuticals as Alternative Approach against Cadmium-Induced Kidney Damage: A Narrative Review.Metabolites · 2023Review
- Relationship between urinary biomarkers of early kidney damage and exposure to inorganic toxins in a pediatric population of Apizaco, Tlaxcala, Mexico.Journal of nephrology · 2023Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCadmium (Cd) and lead (Pb) are widespread environmental contaminants that are known nephrotoxins. However, their nephrotoxic effects at low-environmental exposure levels are debated.
objectiveWe examined the association of blood Pb (B-Pb), blood Cd (B-Cd), urinary Pb (U-Pb) and urinary Cd (U-Cd) with estimated glomerular filtration rate (eGFR) and urinary albumin (ALB).
methodsWe used multivariate linear regression to analyze the association between B-Pb, B-Cd, U-Pb, and U-Cd with eGFR and ALB in adult participants (≥20 years of age) in NHANES 2007-2012. The dataset was limited to NHANES individuals with both blood and urinary metal measurements.
resultsWe found a statistically significant inverse association between eGFR and B-Cd and statistically significant positive associations between eGFR and both U-Cd and U-Pb, as well as statistically significant associations between ALB and the 3rd and 4th quartiles of U-Cd.
conclusionsThe inverse association between eGFR and B-Cd, in conjunction with positive associations between eGFR and ALB with U-Cd, suggest that U-Cd measurement at low levels of exposure may result from changes in renal excretion of Cd due to kidney function and protein excretion. However, renal effects such as hyperfiltration from Cd-mediated kidney damage or creatinine-specific Cd effects cannot be excluded with this cross-sectional design.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.