Evidence map›Paper›PMID 26852237›Full record

Trial reportTrials2016

Evaluation of short message service and peer navigation to improve engagement in HIV care in South Africa: study protocol for a three-arm cluster randomized controlled trial.

Sheri A Lippman, Starley B Shade, Jeri Sumitani, Julia DeKadt, Jennifer M Gilvydis, Mary Jane Ratlhagana, Jessica Grignon, John Tumbo, Hailey Gilmore, Emily Agnew and 3 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Trials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02417233 (Improving Engagement to HIV Prevention and Care in North West, South Africa), which is not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02417233 nacompletednot on this map

Improving Engagement to HIV Prevention and Care in North West, South Africa

TypeinterventionalSponsorUniversity of California, San FranciscoRan2014 to 2016Enrolled756ConditionsHIVArmsSMS text message, SMS text message + Peer Navigation
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Sheri A LippmanCenter for AIDS Prevention Studies, Department of Medicine, University of California, San Francisco, UCSF Box 0886, 550 16th Street, 3rd Floor, San Francisco, CA, 94143, USA. sheri.lippman@ucsf.edu.
Starley B ShadeCenter for AIDS Prevention Studies, Department of Medicine, University of California, San Francisco, UCSF Box 0886, 550 16th Street, 3rd Floor, San Francisco, CA, 94143, USA. starley.shade@ucsf.edu.
Jeri SumitaniInternational Training and Education Center for Health South Africa, University of Washington, 232 Bronkhorst Street, Pretoria, Republic of South Africa. jsumitani@itech-southafrica.org.
Julia DeKadtInternational Training and Education Center for Health South Africa, University of Washington, 232 Bronkhorst Street, Pretoria, Republic of South Africa. jdekadt@itech-southafrica.org.
Jennifer M GilvydisDepartment of Global Health, University of Washington, Seattle, USA. jmas@uw.edu.
Mary Jane RatlhaganaInternational Training and Education Center for Health South Africa, University of Washington, 232 Bronkhorst Street, Pretoria, Republic of South Africa. MRatlhagana@itech-southafrica.org.
Jessica GrignonInternational Training and Education Center for Health South Africa, University of Washington, 232 Bronkhorst Street, Pretoria, Republic of South Africa. jgrignon@uw.edu.
John TumboDepartment of Family Medicine and Primary Health Care, University of Limpopo - Medical University of Southern Africa campus, Pretoria, South Africa. tumbo@lantic.net.
Hailey GilmoreCenter for AIDS Prevention Studies, Department of Medicine, University of California, San Francisco, UCSF Box 0886, 550 16th Street, 3rd Floor, San Francisco, CA, 94143, USA. hailey.gilmore@ucsf.edu.
Emily AgnewCenter for AIDS Prevention Studies, Department of Medicine, University of California, San Francisco, UCSF Box 0886, 550 16th Street, 3rd Floor, San Francisco, CA, 94143, USA. emily.agnew@ucsf.edu.
Parya SaberiCenter for AIDS Prevention Studies, Department of Medicine, University of California, San Francisco, UCSF Box 0886, 550 16th Street, 3rd Floor, San Francisco, CA, 94143, USA. parya.saberi@ucsf.edu.
Scott BarnhartDepartments of Medicine and Global Health, University of Washington, Seattle, WA, USA. sbht@uw.edu.
Wayne T StewardCenter for AIDS Prevention Studies, Department of Medicine, University of California, San Francisco, UCSF Box 0886, 550 16th Street, 3rd Floor, San Francisco, CA, 94143, USA. wayne.steward@ucsf.edu.
San Francisco AIDS Foundation · USUniversity of California, San Francisco · USSeattle University · USUniversity of Limpopo · ZAUniversity of Washington · US

Funding

Ujima Mentoring ProgramP30MH062246 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALLORY O JOHNSON · 2001 to 2026
$57.4M
Technology-based adaptive treatment strategies for antiretroviral adherenceK23MH097649 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SABERI, PARYA · 2012 to 2016
$890k
NIMH NIH HHS K23 MH097649NIMH NIH HHS P30 MH062246PEPFARPHS HHS U91HA06801
6 · The paper itself

Abstract

backgroundIn countries with a high burden of HIV, such as South Africa, where the epidemic remains the world's largest, improving early uptake of and consistent adherence to antiretroviral therapy could bring substantial HIV prevention gains. However, patients are not linked to or retained in care at rates needed to curtail the epidemic. Two strategies that have demonstrated a potential to stem losses along the HIV care cascade in the sub-Saharan African context are use of text messaging or short message service (SMS) and peer-navigation services. METHODS/

designWe designed a cluster randomized trial to assess the efficacy of an SMS intervention and a peer-navigation intervention to improve retention in care and treatment, timely linkage to care and treatment, medication adherence, and prevention behaviors in South Africa. Eighteen primary and community healthcare clinics in Rustenburg and Moses Kotane Sub-districts in the North West Province were randomized to one of three conditions: SMS intervention (n = 7), peer navigation intervention (n = 7), or standard of care (n = 4). Approximately 42 participants are being recruited at each clinic, which will result in a target of 750 participants. Eligible participants include patients accessing HIV testing or care in a study clinic, recently diagnosed with HIV, aged 18 years or older, and with access to a cellular telephone where they are willing to receive automated SMS with HIV-related messaging. Data collection includes extraction of visit information from clinical files and participant surveys at baseline, 6 months, and 12 months. Intent-to-treat (ITT) analysis will explore differences between randomization arms and the primary outcome of patient retention in care at 12 months following enrollment. We will also explore secondary outcomes including participants' a) timely linkage to care (within 3 months of HIV diagnosis), b) adherence to treatment based on self-report and clinic's medication dispensation dates, and c) condom-use behaviors. DISCUSSION: The findings will allow us to compare the efficacy of two complementary interventions, one that requires fewer resources to implement (SMS) and one (peer navigation) that offers more flexibility in terms of the patient barriers to care that it can address.

trial registrationNCT02417233, registered 12 December 2014.

Indexed as

Clinical ProtocolsText MessagingCosts and Cost AnalysisData CollectionHIV InfectionsHumansOutcome Assessment, Health CareSample SizeSouth Africa

Identifiers

PMID26852237
PMCPMC4744624
OpenAlexW2301589132

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.