SynthesisMalaria journal2016
What is the value of reactive case detection in malaria control? A case-study in India and a systematic review.
Synthesis in Malaria journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03511443 (Evaluation of the Performance of a Highly-sensitive Rapid Diagnostic Test), which is not on this map. Cited by 50 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Performance of a Highly-sensitive Rapid Diagnostic Test (RDT) Versus Conventional RDT, Compared With PCR as the Gold Standard, in Reactive Case Detection of Malaria Infections in Rakhine State, Myanmar
Who cites it
50 citing papers in PubMed, 4 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Reactive Case Detection and Treatment and Reactive Drug Administration for Reducing Malaria Transmission: A Systematic Review and Meta-Analysis.The American journal of tropical medicine and hygiene · 2024Pooled it
- Testing and treatment for malaria elimination: a systematic review.Malaria journal · 2023Pooled it
- Detection of asymptomatic malaria in Asian countries: a meta-analysis of diagnostic accuracy.Malaria journal · 2022Pooled it
- Pooled it
- Reactive, self-administered malaria treatment against asymptomatic malaria infection: results of a cluster randomized controlled trial in The Gambia.Malaria journal · 2021Trial
- Complexities in Defining the Unit of Intervention for Reactive Community-Based Malaria Treatment in the Gambia.Frontiers in public health · 2021Trial
- Malaria risk, treatment-seeking, and prevention in Northeastern India: clinic-based surveillance of persistent transmission.Malaria journal · 2025Article
- Influence of Household Roof Types on the Development of Plasmodium vivax in Anopheles stephensi Mosquitoes.The American journal of tropical medicine and hygiene · 2025Article
- Implementation and fidelity of reactive surveillance and response strategies for malaria elimination: a systematic review and meta-analysis.BMJ public health · 2025Article
- Challenges in diagnosis of clinical and subclinical Plasmodium falciparum infections in Ghana and feasibility of reactive interventions to shrink the subclinical reservoir.Malaria journal · 2024Article
- Risk Factor Analysis of Cutaneous Leishmaniasis in Sri Lanka through a Nationwide Survey.The American journal of tropical medicine and hygiene · 2024Article
- Quantifying the impact of interventions against Plasmodium vivax: A model for country-specific use.Epidemics · 2024Article
- The contribution of active case detection to malaria elimination in Thailand.BMJ global health · 2023Article
- How can the complex epidemiology of malaria in India impact its elimination?Trends in parasitology · 2023Review
- Reactive Case Detection Strategy for Malaria Control and Elimination: A 12 Year Systematic Review and Meta-Analysis from 25 Malaria-Endemic Countries.Tropical medicine and infectious disease · 2023Review
- The impact of reactive case detection on malaria transmission in Zanzibar in the presence of human mobility.Epidemics · 2022Article
- Advances in Basic and Translational Research as Part of the Center for the Study of Complex Malaria in India.The American journal of tropical medicine and hygiene · 2022Article
- Implementation and success factors from Thailand's 1-3-7 surveillance strategy for malaria elimination.Malaria journal · 2021Article
- Understanding adherence to reactive treatment of asymptomatic malaria infections in The Gambia.Scientific reports · 2021Article
- Reactive Case Detection (RACD) and foci investigation strategies in malaria control and elimination: a review.Malaria journal · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundReactive case detection (RCD) for malaria is a strategy to identify additional malaria infections in areas of low malaria transmission and can complement passive surveillance. This study describes experiences with RCD in two Indian sites, and aimed to synthesize experiences with RCD across endemic countries.
methodsRCD programmes were piloted in two urban areas of India with a low prevalence of mainly Plasmodium vivax malaria in 2014. Cases were identified in a clinic by microscopy and contacts were screened within 2 weeks; PCR, in addition to microscopy, was used to detect Plasmodium parasites. A systematic review was conducted to identify RCD experiences in the literature.
resultsIn Chennai, 868 contacts were enrolled for 18 index cases of clinical malaria; in Nadiad, 131 contacts were enrolled for 20 index cases. No new malaria infections were detected in Nadiad among contacts, and four new infections were detected in Chennai (three P. vivax and one Plasmodium falciparum), of which two were among household members of index cases. An additional five studies describing results from an RCD strategy were identified in the literature: four in Africa and one in Thailand. Including the results from India, the average number of contacts screened per index case in a total of seven studies ranged from four to 50, and 126 in a case study in Thailand with one index case. Malaria was detected in 0-45 % of the contacted persons. The average number of index cases needed to be traced to find one new case of malaria ranged from one to five, and could not be assessed in one study in India (no contacts positive for 20 cases). Sharing the household with an index case was associated with a five-fold increased risk of malaria compared to contacts from households without an index case (pooled risk ratio 5.29, 95 % CI 3.31-8.47, I(2) 0 %, four studies).
conclusionsRCD in areas of low malaria transmission is a labour-intensive strategy, and its benefit is not clear. Studies are needed to assess how RCD can be optimized or into alternatives where interventions are targeted to family members or hotspots.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.