ArticleThe Journal of allergy and clinical immunology2016
Indoor microbial communities: Influence on asthma severity in atopic and nonatopic children.
Article in The Journal of allergy and clinical immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.
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Who cites it
65 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Indoor Microbiome: Sampling, Analysis and Emerging Trends.Environmental microbiology reports · 2026Pooled it
- The classroom microbiome and asthma morbidity in children attending 3 inner-city schools.The Journal of allergy and clinical immunology · 2018Trial
- Domestic fungal exposure and asthma morbidity in New York City children following Superstorm Sandy.Journal of exposure science & environmental epidemiology · 2026Article
- Experiences with household mold and perceptions of microbiome engineering to mitigate mold.Frontiers in public health · 2026Article
- Article
- Exposure to elevated relative humidity in laboratory chambers alters fungal gene expression in dust from the International Space Station (ISS).Scientific reports · 2025Article
- Indoor and Outdoor Fungal Allergens and Impacts on Respiratory Allergic Disease.The journal of allergy and clinical immunology. In practice · 2025Review
- Indoor allergen exposure in relation to sleep health among US adults.The journal of allergy and clinical immunology. Global · 2025Article
- Associations Between Indoor Fungal Community Structures and Environmental Factors: Insights from the Evidence-Driven Indoor Air-Quality Improvement Study.Journal of fungi (Basel, Switzerland) · 2025Article
- More diverse school microbiota may provide better protection against respiratory infections for school staff.Building and environment · 2025Article
- Airway Microbiota Profiles in Children With and Without Asthma: A Comparative Study.Journal of asthma and allergy · 2025Article
- The association between Toxoplasma gondii infection and asthma in the United States: A cross-sectional survey analysis.PloS one · 2025Article
- Climate change and indoor biological exposures: a hidden risk to immune health.Frontiers in public health · 2025Article
- Predicting how varying moisture conditions impact the microbiome of dust collected from the International Space Station.Microbiome · 2024Article
- The Role of Biodiversity in the Development of Asthma and Allergic Sensitization: A State-of-the-Science Review.Environmental health perspectives · 2024Review
- Fungal diversity in homes and asthma morbidity among school-age children in New York City.Environmental research · 2023Article
- Indoor metabolites and chemicals outperform microbiome in classifying childhood asthma and allergic rhinitis.Eco-Environment & Health · 2023Article
- Fungi in Early-Life House Dust Samples and the Development of Asthma: A Birth Cohort Study.Annals of the American Thoracic Society · 2023Article
- Metagenomics reveals novel microbial signatures of farm exposures in house dust.medRxiv : the preprint server for health sciences · 2023Article
- PersistingFrontiers in cellular and infection microbiology · 2023Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundAllergic and nonallergic asthma severity in children can be affected by microbial exposures.
objectiveWe sought to examine associations between exposures to household microbes and childhood asthma severity stratified by atopic status.
methodsParticipants (n = 196) were selected from a cohort of asthmatic children in Connecticut and Massachusetts. Children were grouped according to asthma severity (mild with no or minimal symptoms and medication or moderate to severe persistent) and atopic status (determined by serum IgE levels). Microbial community structure and concentrations in house dust were determined by using next-generation DNA sequencing and quantitative PCR. Logistic regression was used to explore associations between asthma severity and exposure metrics, including richness, taxa identification and quantification, community composition, and concentration of total fungi and bacteria.
resultsAmong all children, increased asthma severity was significantly associated with an increased concentration of summed allergenic fungal species, high total fungal concentrations, and high bacterial richness by using logistic regression in addition to microbial community composition by using the distance comparison t test. Asthma severity in atopic children was associated with fungal community composition (P = .001). By using logistic regression, asthma severity in nonatopic children was associated with total fungal concentration (odds ratio, 2.40; 95% CI, 1.06-5.44). The fungal genus Volutella was associated with increased asthma severity in atopic children (P = .0001, q = 0.04). The yeast genera Kondoa might be protective; Cryptococcus species might also affect asthma severity.
conclusionAsthma severity among this cohort of children was associated with microbial exposure, and associations differed based on atopic status.
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