ReviewNeuroscience2017
Neurophysiology of rule switching in the corticostriatal circuit.
Review in Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Neural Signatures of Cognitive Flexibility and Reward Sensitivity Following Nicotinic Receptor Stimulation in Dependent Smokers: A Randomized Trial.JAMA psychiatry · 2017Trial
- Psychedelics do not always enhance cognitive flexibility: The potential role of time-varying effects on reward learning processes.Neuroscience and biobehavioral reviews · 2026Review
- Spatially heterogeneous acetylcholine dynamics in the striatum promote behavioral flexibility.Nature communications · 2025Article
- Enhanced cognitive flexibility and phasic striatal dopamine dynamics in a mouse model of low striatal tonic dopamine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Activation of prefrontal cortex and striatal regions in rats after shifting between rules in a T-maze.Learning & memory (Cold Spring Harbor, N.Y.) · 2023Article
- Acute psilocybin enhances cognitive flexibility in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Exploration behavior after reversals is predicted by STN-GPe synaptic plasticity in a basal ganglia model.iScience · 2023Article
- Acute psilocybin enhances cognitive flexibility in rats.bioRxiv : the preprint server for biology · 2023Article
- The rodent medial prefrontal cortex and associated circuits in orchestrating adaptive behavior under variable demands.Neuroscience and biobehavioral reviews · 2022Review
- Suppression of pyramidal neuron G protein-gated inwardly rectifying K+ channel signaling impairs prelimbic cortical function and underlies stress-induced deficits in cognitive flexibility in male, but not female, mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Remifentanil self-administration in mice promotes sex-specific prefrontal cortex dysfunction underlying deficits in cognitive flexibility.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Cross-hemispheric gamma synchrony between prefrontal parvalbumin interneurons supports behavioral adaptation during rule shift learning.Nature neuroscience · 2020Article
- Stereotyped, automatized and habitual behaviours: are they similar constructs under the control of the same cerebral areas?AIMS neuroscience · 2020Review
- Bridging the species gap in translational research for neurodevelopmental disorders.Neurobiology of learning and memory · 2019Article
- Prefrontal cortex and cognitive control: new insights from human electrophysiology.F1000Research · 2019Review
- A novel multichoice touchscreen paradigm for assessing cognitive flexibility in mice.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- Cognitive control involves theta power within trials and beta power across trials in the prefrontal-subthalamic network.Brain : a journal of neurology · 2018Article
- Basal ganglia mechanisms in action selection, plasticity, and dystonia.European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2018Review
- Rule Encoding in Orbitofrontal Cortex and Striatum Guides Selection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The ability to adjust behavioral responses to cues in a changing environment is crucial for survival. Activity in the medial Prefrontal Cortex (mPFC) is thought to both represent rules to guide behavior as well as detect and resolve conflicts between rules in changing contingencies. While lesion and pharmacological studies have supported a crucial role for mPFC in this type of set-shifting, an understanding of how mPFC represents current rules or detects and resolves conflict between different rules is still unclear. Meanwhile, medial dorsal striatum (mDS) receives major projections from mPFC and neural activity of mDS is closely linked to action selection, making the mDS a potential major player for enacting rule-guided action policies. However, exactly what is signaled by mPFC and how this impacts neural signals in mDS is not well known. In this review, we will summarize what is known about neural signals of rules and set shifting in both prefrontal cortex and dorsal striatum, as well as provide questions and directions for future experiments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.