Evidence map›Paper›PMID 26851723›Full record

ArticleEnvironmental research2016

Non-thyroid cancer incidence in Belarusian residents exposed to Chernobyl fallout in childhood and adolescence: Standardized Incidence Ratio analysis, 1997-2011.

Evgenia Ostroumova, Maureen Hatch, Alina Brenner, Eldar Nadyrov, Ilya Veyalkin, Olga Polyanskaya, Vasilina Yauseyenka, Semion Polyakov, Leonid Levin, Lydia Zablotska and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Somatic health effects of Chernobyl: 30 years on.European journal of epidemiology · 2017
    Pooled it
  2. Article
  3. Review
  4. Childhood leukemia in Ukraine after the Chornobyl accident.Radiation and environmental biophysics · 2019
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Evgenia OstroumovaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 9609 Medical Center Drive, MSC 9776, Bethesda, 20892 MD, USA. Electronic address: ostroumovae@iarc.fr.
Maureen HatchDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 9609 Medical Center Drive, MSC 9776, Bethesda, 20892 MD, USA. Electronic address: hatchm@mail.nih.gov.
Alina BrennerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 9609 Medical Center Drive, MSC 9776, Bethesda, 20892 MD, USA. Electronic address: brennera@mail.nih.gov.
Eldar NadyrovThe Republican Research Center for Radiation Medicine and Human Ecology, 290 Ilyicha Street, Gomel 246040, Belarus. Electronic address: nadyrov2006@rambler.ru.
Ilya VeyalkinThe Republican Research Center for Radiation Medicine and Human Ecology, 290 Ilyicha Street, Gomel 246040, Belarus. Electronic address: veyalkin@mail.ru.
Olga PolyanskayaThe Republican Research Center for Radiation Medicine and Human Ecology, 290 Ilyicha Street, Gomel 246040, Belarus. Electronic address: polyanskaya@tut.by.
Vasilina YauseyenkaThe Republican Research Center for Radiation Medicine and Human Ecology, 290 Ilyicha Street, Gomel 246040, Belarus. Electronic address: yaus@mail.ru.
Semion PolyakovState Institution "Republican Scientific and Practical Center for Medical Technologies, Informatization, Administration and Management of Health", 7-a Petrus Brovka Street, Minsk 220600, Belarus. Electronic address: spolyakov@belcmt.by.
Leonid LevinCancer Registry, State Establishment "N.N.Alexandrov National Cancer Center of Belarus for Oncology and Medical Radiology", P.O., Lesnoy 223040, Belarus. Electronic address: llevin@omr.med.by.
Lydia ZablotskaUniversity of California, San Francisco, 3333 California Street, Laurel Heights, San Francisco, 94118 CA, USA. Electronic address: lydia.zablotska@ucsf.edu.
Alexander RozhkoThe Republican Research Center for Radiation Medicine and Human Ecology, 290 Ilyicha Street, Gomel 246040, Belarus. Electronic address: rcrm@tut.by.
Kiyohiko MabuchiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 9609 Medical Center Drive, MSC 9776, Bethesda, 20892 MD, USA. Electronic address: mabuchik@mail.nih.gov.
Republican Research Center for Radiation Medicine and Human Ecology · BYNational Institutes of Health · USNational Cancer Institute · USN.N. Alexandrov National Cancer Centre · BYRSPC MT · BYUniversity of California, San Francisco · US

Funding

Studies of Populations Exposed to Environmental Sources of RadiationZIACP010132 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI CAHOON, ELIZABETH · 2009 to 2025
$35.2M
Intramural NIH HHSNCI NIH HHS HHSN261201300002C
6 · The paper itself

Abstract

backgroundWhile an increased risk of thyroid cancer from post-Chernobyl exposure to Iodine-131 (I-131) in children and adolescents has been well-documented, risks of other cancers or leukemia as a result of residence in radioactively contaminated areas remain uncertain.

methodsWe studied non-thyroid cancer incidence in a cohort of about 12,000 individuals from Belarus exposed under age of 18 years to Chernobyl fallout (median age at the time of Chernobyl accident of 7.9 years). During 15 years of follow-up from1997 through 2011, 54 incident cancers excluding thyroid were identified in the study cohort with 142,968 person-years at risk. We performed Standardized Incidence Ratio (SIR) analysis of all solid cancers excluding thyroid (n=42), of leukemia (n=6) and of lymphoma (n=6).

resultsWe found no significant increase in the incidence of non-thyroid solid cancer (SIR=0.83, 95% Confidence Interval [CI]: 0.61; 1.11), lymphoma (SIR=0.66, 95% CI: 0.26; 1.33) or leukemia (SIR=1.78, 95% CI: 0.71; 3.61) in the study cohort as compared with the sex-, age- and calendar-time-specific national rates. These findings may in part reflect the relatively young age of study subjects (median attained age of 33.4 years), and long latency for some radiation-related solid cancers.

conclusionsWe found no evidence of statistically significant increases in solid cancer, lymphoma and leukemia incidence 25 years after childhood exposure in the study cohort; however, it is important to continue follow-up non-thyroid cancers in individuals exposed to low-level radiation at radiosensitive ages.

Indexed as

Chernobyl Nuclear AccidentAdolescentChildChild, PreschoolCohort StudiesHumansIncidenceInfantInfant, NewbornLeukemiaLymphomaNeoplasms, Radiation-InducedRepublic of BelarusRisk FactorsChernobylLeukemiaLymphomaSolid cancerStandardized Incidence Ratio (SIR)

Identifiers

PMID26851723
PMCPMC4821667
OpenAlexW2265522628

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.