ReviewBiomaterials2016
Multifunctional coatings to simultaneously promote osseointegration and prevent infection of orthopaedic implants.
Review in Biomaterials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 169 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
169 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effectiveness of strontium/silver-based titanium surface coatings in improving antibacterial and osteogenic implant characteristics: a systematic review ofFrontiers in bioengineering and biotechnology · 2024Pooled it
- Incidence of periprosthetic joint infection after primary total hip arthroplasty is underestimated: a synthesis of meta-analysis and bibliometric analysis.Journal of orthopaedic surgery and research · 2023Pooled it
- Copper-coated carbon nanotube surfaces for inhibiting biofilm formation byCell surface (Amsterdam, Netherlands) · 2026Review
- Janus bilayer coating of functional quaternized chitosan and borate bioactive glass for antibacterial protection and osseointegration.Biomaterials advances · 2026Article
- Bacterial Adhesion on Orthopedic Titanium Implants Coated with Silver-Doped Hydroxyapatite and Chitosan.Molecules (Basel, Switzerland) · 2026Article
- Nature-inspired biomaterial innovations to counter medical device-associated infections.Biomaterials science · 2026Review
- Translational Progress and Clinical Challenges in Bioengineered Bone and Joint Repair.Biomedicines · 2026Review
- Research Progress and Translational Perspectives of Piezoelectric Materials in Dental Implant Surface Engineering.Journal of functional biomaterials · 2026Review
- An Experimental Study on 3D-Printed Gyroid-Shaped TC4 Porous Scaffolds Guiding Angiogenesis and Osteogenesis in Bone Defect Areas.ACS biomaterials science & engineering · 2026Article
- Advances in antibiofilm strategies for medical implant-associated infections: emerging technologies and translational challenges.Frontiers in microbiology · 2026Review
- SHED-exosomes functionalized micro-nano bioactive glass/PCL membrane regulates macrophage polarization and promotes osteogenic differentiation.Journal of applied oral science : revista FOB · 2026Article
- Enhanced Osseointegration, Osteogenic Differentiation and Adherence Behaviour of Healthy Human Osteoblasts on a Roughened Titanium Surface by Vitamin K2 and Vitamin D3.Materials (Basel, Switzerland) · 2025Article
- Electrospun Polycaprolactone Membranes Loaded with Gentamicin and Nano-Hidroxyapatite for Guided Bone Regeneration.Biomedicines · 2025Article
- Porous Structures, Surface Modifications, and Smart Technologies for Total Ankle Arthroplasty: A Narrative Review.Bioengineering (Basel, Switzerland) · 2025Review
- Resin Composites with Anti-Biofouling Zwitterionic Polymer and Silica/Zirconia Filler for Digital Light Processing (DLP) of Dental Protheses.Materials (Basel, Switzerland) · 2025Article
- Promoting implant osseointegration via the osteoblast-selective β-amino acid polymer strategy.Nature communications · 2025Article
- Electrospinning Enables Opportunity for Green and Effective Antibacterial Coatings of Medical Devices.Journal of functional biomaterials · 2025Review
- Dual Antibacterial and Soft-Tissue-Integrative Effect of Combined Strontium Acetate and Silver Nitrate on Peri-Implant Environment: Insights from Multispecies Biofilms and a 3D Coculture Model.ACS applied materials & interfaces · 2025Article
- Bioglasses Versus Bioactive Calcium Phosphate Derivatives as Advanced Ceramics in Tissue Engineering: Comparative and Comprehensive Study, Current Trends, and Innovative Solutions.Journal of functional biomaterials · 2025Review
- Functionalized zeolite regulates bone metabolic microenvironment.Materials today. Bio · 2025Review
109 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The two leading causes of failure for joint arthroplasty prostheses are aseptic loosening and periprosthetic joint infection. With the number of primary and revision joint replacement surgeries on the rise, strategies to mitigate these failure modes have become increasingly important. Much of the recent work in this field has focused on the design of coatings either to prevent infection while ignoring bone mineralization or vice versa, to promote osseointegration while ignoring microbial susceptibility. However, both coating functions are required to achieve long-term success of the implant; therefore, these two modalities must be evaluated in parallel during the development of new orthopaedic coating strategies. In this review, we discuss recent progress and future directions for the design of multifunctional orthopaedic coatings that can inhibit microbial cells while still promoting osseointegration.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.