Evidence map›Paper›PMID 26851224›Full record

ArticleBriefings in bioinformatics2017

Bridging semantics and syntax with graph algorithms-state-of-the-art of extracting biomedical relations.

Yuan Luo, Özlem Uzuner, Peter Szolovits

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Briefings in bioinformatics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 85 citations in OpenAlex.

  1. A Guide for Spatial Omics Technologies: Innovation, Evaluation, and Application.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  2. LitTx: A New Treatment Relation Extraction Dataset.LREC ... International Conference on Language Resources & Evaluation : [proceedings]. International Conference on Language Resources & Evaluation · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. BertSRC: transformer-based semantic relation classification.BMC medical informatics and decision making · 2022
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Emerging Priorities for Microbiome Research.Frontiers in microbiology · 2020
    Review
  17. Extracting entities with attributes in clinical text via joint deep learning.Journal of the American Medical Informatics Association : JAMIA · 2019
    Article
  18. Article
  19. deepBioWSD: effective deep neural word sense disambiguation of biomedical text data.Journal of the American Medical Informatics Association : JAMIA · 2019
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Yuan Luo
Özlem Uzuner
Peter Szolovits
Massachusetts Institute of Technology · USNorthwestern University · USUniversity at Albany, State University of New York · US

Funding

Informatics for Integrating Biology/ the Bedside (RMI)U54LM008748 · NLM · BRIGHAM AND WOMEN'S HOSPITAL · PI KOHANE, ISAAC S. · 2004 to 2013
$39.0M
TrainingU54HG007963 · NHGRI · HARVARD MEDICAL SCHOOL · PI KOHANE, ISAAC S. · 2014 to 2018
$18.3M
NHGRI NIH HHS U54 HG007963NLM NIH HHS U54 LM008748
6 · The paper itself

Abstract

Research on extracting biomedical relations has received growing attention recently, with numerous biological and clinical applications including those in pharmacogenomics, clinical trial screening and adverse drug reaction detection. The ability to accurately capture both semantic and syntactic structures in text expressing these relations becomes increasingly critical to enable deep understanding of scientific papers and clinical narratives. Shared task challenges have been organized by both bioinformatics and clinical informatics communities to assess and advance the state-of-the-art research. Significant progress has been made in algorithm development and resource construction. In particular, graph-based approaches bridge semantics and syntax, often achieving the best performance in shared tasks. However, a number of problems at the frontiers of biomedical relation extraction continue to pose interesting challenges and present opportunities for great improvement and fruitful research. In this article, we place biomedical relation extraction against the backdrop of its versatile applications, present a gentle introduction to its general pipeline and shared resources, review the current state-of-the-art in methodology advancement, discuss limitations and point out several promising future directions.

Indexed as

SemanticsAlgorithmsComputational BiologyData MiningHumansbiomedical relation extractionclinical narrativesgraph miningmachine learningnatural language processingscientific literature

Identifiers

PMID26851224
PMCPMC5221425
OpenAlexW2252979829

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.