Evidence map›Paper›PMID 26851143›Full record

ArticleSchizophrenia research2016

Measuring the capacity for auditory system plasticity: An examination of performance gains during initial exposure to auditory-targeted cognitive training in schizophrenia.

Melissa Tarasenko, Veronica B Perez, Sean T Pianka, Sophia Vinogradov, David L Braff, Neal R Swerdlow, Gregory A Light

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02634684 (Pharmacologic Augmentation of Neurocognition and Cognitive Training in Psychosis), which is not on this map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02634684 phase2completednot on this map

Pharmacologic Augmentation of Neurocognition and Cognitive Training in Psychosis

TypeinterventionalSponsorUniversity of California, San DiegoRan2014 to 2020Enrolled82ConditionsSchizophreniaArmsDextroamphetamine, Placebo
3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Trial
  2. Memantine effects on auditory discrimination and training in schizophrenia patients.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020
    Trial
  3. Trial
  4. Trial
  5. Trial
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  7. Neurophysiologic measures of target engagement predict response to auditory-based cognitive training in treatment refractory schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019
    Trial
  8. Trial
  9. Article
  10. Article
  11. Auditory perceptual discomfort and low-hearing tolerance in the first episode psychosis.Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS · 2022
    Article
  12. Article
  13. Article
  14. Individual Alpha Peak Frequency Moderates Transfer of Learning in Cognitive Remediation of Schizophrenia.Journal of the International Neuropsychological Society : JINS · 2020
    Article
  15. Article
  16. Article
  17. Article
  18. Mismatch Negativity is a Sensitive and Predictive Biomarker of Perceptual Learning During Auditory Cognitive Training in Schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Melissa TarasenkoVISN-22 Mental Illness, Research, Education and Clinical Center (MIRECC), VA San Diego Healthcare System, La Jolla, CA, USA; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Veronica B PerezVISN-22 Mental Illness, Research, Education and Clinical Center (MIRECC), VA San Diego Healthcare System, La Jolla, CA, USA; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Sean T PiankaDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Sophia VinogradovDepartment of Psychiatry, University of California, San Francisco, San Francisco, CA, USA; Mental Health Service, San Francisco Department of Veterans Affairs Medical Center, San Francisco, CA, USA.
David L BraffVISN-22 Mental Illness, Research, Education and Clinical Center (MIRECC), VA San Diego Healthcare System, La Jolla, CA, USA; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Neal R SwerdlowDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Gregory A LightVISN-22 Mental Illness, Research, Education and Clinical Center (MIRECC), VA San Diego Healthcare System, La Jolla, CA, USA; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA. Electronic address: glight@ucsd.edu.

Funding

UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
San Diego Clinical and Translational Research InstituteUL1TR000100 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S · 2012 to 2015
$19.7M
Accelerated Inflammaging in SchizophreniaR01MH094151 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI EYLER, LISA T · 2012 to 2021
$7.4M
The Genetics of Endophenotypes and SchizophreniaR01MH065571 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRAFF, DAVID L. · 2003 to 2013
$7.0M
SENSORY GATING &HABITUATION IN SCHIZOPHRENIAR01MH042228 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRAFF, DAVID L. · 1987 to 2015
$6.5M
6/9-Predictors and Mechanisms of Conversion to PsychosisU01MH081944 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CADENHEAD, KRISTIN S. · 2008 to 2018
$4.9M
Pharmacologic augmentation of neurocognition and cognitive training in psychosisR01MH059803 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SWERDLOW, NEAL R · 1999 to 2018
$4.5M
Memantine effects on sensorimotor gating and neurocognition in schizophreniaR01MH094320 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SWERDLOW, NEAL R · 2012 to 2020
$2.6M
SENSORY GATING AND HABITUATION IN SCHIZOPHRENIAR37MH042228 · NIMH · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI BRAFF, DAVID L. · 1993 to 2002
$1.3M
Biomarker Strategies for Medication-Enhanced Cognitive Training in SchizophreniaR34MH093453 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SWERDLOW, NEAL R · 2011 to 2013
$689k
NCATS NIH HHS UL1 TR000100NCATS NIH HHS UL1TR000100NIGMS NIH HHS T32 GM008042NIMH NIH HHS MH094320NIMH NIH HHS MH42228NIMH NIH HHS MH59803NIMH NIH HHS R01 MH042228NIMH NIH HHS R01 MH059803NIMH NIH HHS R01 MH065571NIMH NIH HHS R01 MH094151NIMH NIH HHS R01 MH094320NIMH NIH HHS R34 MH093453NIMH NIH HHS R37 MH042228NIMH NIH HHS U01 MH081944
6 · The paper itself

Abstract

unlabelledAuditory-Targeted Cognitive Training (ATCT), which aims to improve auditory information processing efficiency, has shown great promise for remediating cognitive deficits in schizophrenia (SZ). However, there is substantial heterogeneity in the degree of cognitive gains made during ATCT, and some patients show negligible benefit after completing therapeutic doses of training. Identifying individual differences that can be measured early in the course of ATCT and that predict subsequent cognitive benefits from the intervention is therefore important. The present study calculated a variety of performance metrics during the initial hour of exposure to ATCT Sound Sweeps, a frequency discrimination time-order judgment task, and investigated the relationships of these metrics to demographic, clinical, and cognitive characteristics of SZ patients. Thirty-seven SZ outpatients completed measures of auditory attention, working memory, verbal memory, and executive functioning, followed by 1h of Sound Sweeps training. Performance metrics, calculated after the first training level, the first training stage (Levels 1-4), and the entire hour of training included baseline and best auditory processing speed (APS) scores, as well as percent improvement in APS after training. The number of training levels completed by each participant was also calculated. Baseline and best APS correlated with performance in all cognitive domains, whereas APS improvements only correlated with verbal memory. Number of training levels completed was marginally associated with auditory attention only.

conclusionsSound Sweeps performance correlates with a range of neurocognitive abilities. APS improvement may provide a particularly sensitive index of "plasticity potential" within the neural network underlying verbal learning and memory.

Indexed as

Auditory PerceptionNeuronal PlasticitySchizophrenic PsychologyAdultAttentionCognitive Behavioral TherapyExecutive FunctionFemaleHumansMaleMemory, Short-TermMiddle AgedNeuropsychological TestsSchizophreniaTreatment OutcomeAuditory processingCognitionCognitive remediationPsychosisSchizophreniaTraining

Identifiers

PMID26851143
PMCPMC5072522

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.