Evidence map›Paper›PMID 26850738›Full record

ArticleBrain connectivity2016

Atypical Structural Connectome Organization and Cognitive Impairment in Young Survivors of Acute Lymphoblastic Leukemia.

Shelli R Kesler, Meike Gugel, Emily Huston-Warren, Christa Watson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain connectivity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  13. The association of environmental factors with neurocognitive outcomes in survivors of childhood acute lymphoblastic leukemia (ALL).Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Article
  14. Article
  15. Article
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  18. A Cross-Sectional Exploration of Cytokine-Symptom Networks in Breast Cancer Survivors Using Network Analysis.The Canadian journal of nursing research = Revue canadienne de recherche en sciences infirmieres · 2021
    Article
  19. Brain Imaging in Pediatric Cancer Survivors: Correlates of Cognitive Impairment.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shelli R Kesler1 Department of Neuro-Oncology, University of Texas MD Anderson Cancer Center , Houston, Texas.
Meike Gugel2 Department of Psychiatry and Behavioral Sciences, Stanford University , Stanford, California.
Emily Huston-Warren1 Department of Neuro-Oncology, University of Texas MD Anderson Cancer Center , Houston, Texas.
Christa Watson3 Department of Neurology, Dyslexia Center and Memory and Aging Center, University of California at San Francisco , San Francisco, California.

Funding

Neurobiologic Mechanisms of Cognitive Dysfunction and Decline in MedulloblastomaK07CA134639 · NCI · STANFORD UNIVERSITY · PI KESLER, SHELLI R · 2009 to 2013
$823k
Machine Learning Comparison of Brain Anatomy in Cancer and Alzheimer's DiseaseR03CA191559 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KESLER, SHELLI R · 2015 to 2016
$160k
NCI NIH HHS K07 CA134639NCI NIH HHS R03 CA191559
6 · The paper itself

Abstract

Survivors of pediatric acute lymphoblastic leukemia (ALL) are at increased risk for cognitive impairments that disrupt everyday functioning and decrease quality of life. The specific biological mechanisms underlying cognitive impairment following ALL remain largely unclear, but previous studies consistently demonstrate significant white matter pathology. We aimed to extend this literature by examining the organization of the white matter connectome in young patients with a history of ALL treated with chemotherapy only. We applied graph theoretical analysis to diffusion tensor imaging obtained from 31 survivors of ALL age 5-19 years and 39 matched healthy controls. Results indicated significantly lower small-worldness (p = 0.007) and network clustering coefficient (p = 0.019), as well as greater cognitive impairment (p = 0.027) in the ALL group. Regional analysis indicated that clustered connectivity in parietal, frontal, hippocampal, amygdalar, thalamic, and occipital regions was altered in the ALL group. Random forest analysis revealed a model of connectome and demographic variables that could automatically classify survivors of ALL as having cognitive impairment or not (accuracy = 0.89, p < 0.0001). These findings provide further evidence of brain injury in young survivors of ALL, even those without a history of central nervous system (CNS) disease or cranial radiation. Efficiency of local information processing, reorganization of hub connectivity, and cognitive reserve may contribute to cognitive outcome in these children. Certain connectome properties showed U-shaped relationships with cognitive impairment suggesting an optimal range of regional connectivity.

Indexed as

AdolescentBrainBrain MappingChildCognitionCognitive DysfunctionConnectomeDiffusion Tensor ImagingFemaleHumansMaleMental ProcessesNerve NetPrecursor Cell Lymphoblastic Leukemia-LymphomaSurvivorsWhite Mattercancercognitionconnectomediffusion tensor imaging (DTI)

Identifiers

PMID26850738
PMCPMC4876554

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.