ArticleMolecular ecology2016
Population genomics of the filarial nematode parasite Wuchereria bancrofti from mosquitoes.
Article in Molecular ecology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Genetic structuring and estimation of reproductive adults in Onchocerca volvulus: A genome-wide analysis across hosts and regions.PLoS neglected tropical diseases · 2025Article
- Genome-Wide Analysis Reveals Key Genes and MicroRNAs Related to Pathogenic Mechanism inPathogens (Basel, Switzerland) · 2024Article
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- Phylogenomic Analysis of 155 Helminth Species Reveals Widespread Absence of Oxygen Metabolic Capacity.Genome biology and evolution · 2023Article
- Selective whole-genome amplification reveals population genetics of Leishmania braziliensis directly from patient skin biopsies.PLoS pathogens · 2023Article
- X-treme loss of sequence diversity linked to neo-X chromosomes in filarial nematodes.PLoS neglected tropical diseases · 2021Article
- The community-curated Pristionchus pacificus genome facilitates automated gene annotation improvement in related nematodes.BMC genomics · 2021Article
- Characterizing Repeats in Two Whole-Genome Amplification Methods in the Reniform Nematode Genome.International journal of genomics · 2021Article
- Article
- De novo Assembly of the Brugia malayi Genome Using Long Reads from a Single MinION Flowcell.Scientific reports · 2019Article
- The global diversity of Haemonchus contortus is shaped by human intervention and climate.Nature communications · 2019Article
- Human Migration and the Spread of the Nematode Parasite Wuchereria bancrofti.Molecular biology and evolution · 2019Article
- Influence of seasonal variation on reported filarial attacks among people living with lymphedema in Ghana.BMC infectious diseases · 2019Article
- Genomic Epidemiology in Filarial Nematodes: Transforming the Basis for Elimination Program Decisions.Frontiers in genetics · 2019Review
- SeqDeχ: A Sequence Deconvolution Tool for Genome Separation of Endosymbionts From Mixed Sequencing Samples.Frontiers in genetics · 2019Article
- An Evolutionary Perspective on Vector-Borne Diseases.Frontiers in genetics · 2019Review
- The population genetics of parasitic nematodes of wild animals.Parasites & vectors · 2018Review
- Understanding heterogeneities in mosquito-bite exposure and infection distributions for the elimination of lymphatic filariasis.Proceedings. Biological sciences · 2018Article
- Highlights on the Application of Genomics and Bioinformatics in the Fight Against Infectious Diseases: Challenges and Opportunities in Africa.Frontiers in genetics · 2018Review
- Draft genome sequence of the Wolbachia endosymbiont of Wuchereria bancrofti wWb.Pathogens and disease · 2017Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
Abstract
Wuchereria bancrofti is a parasitic nematode and the primary cause of lymphatic filariasis--a disease specific to humans. W. bancrofti currently infects over 90 million people throughout the tropics and has been acknowledged by the world health organization as a vulnerable parasite. Current research has focused primarily on the clinical manifestations of disease and little is known about the evolutionary history of W. bancrofti. To improve upon knowledge of the evolutionary history of W. bancrofti, we whole genome sequenced 13 W. bancrofti larvae. We circumvent many of the difficulties of multiple infections by sampling larvae directly from mosquitoes that were experimentally inoculated with infected blood. To begin, we used whole genome data to reconstruct the historical population size. Our results support a history of fluctuating population sizes that can be correlated with human migration and fluctuating mosquito abundances. Next, we reconstructed the putative pedigree of W. bancrofti worms within an infection using the kinship coefficient. We deduced that there are full-sib and half-sib relationships residing within the same larval cohort. Through combined analysis of the mitochondrial and nuclear genomes we concluded that this is likely a results of polyandrous mating, the first time reported for W. bancrofti. Lastly, we scanned the genomes for signatures of natural selection. Annotation of putative selected regions identified proteins that may have aided in a parasitic life style or may have evolved to protect against current drug treatments. We discuss our results in the greater context of understanding the biology of an animal with a unique life history and ecology.
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Registered trials
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