ArticleJournal of clinical pathology1989
Use of APAAP technique on paraffin wax embedded bone marrow trephines.
Article in Journal of clinical pathology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- An enhanced immunocytochemical method for staining bone marrow trephine sections.Journal of clinical pathology · 1997Trial
- Age-Related Alterations in SIBLING Proteins and Dentin Micro-Architecture: Morphological and Molecular Associations.Life (Basel, Switzerland) · 2025Article
- Antibody panel in diagnosis of lymphoid neoplasms.Journal of clinical pathology · 1998Article
- A panel of antibodies for the immunostaining of Bouin's fixed bone marrow trephine biopsies.Journal of clinical pathology · 1997Article
- Bone marrow trephine biopsy in lymphoproliferative disease.Journal of clinical pathology · 1992Article
- Immunohistochemical evaluation of bone marrow lymphoid nodules in chronic myeloproliferative disorders.Virchows Archiv. A, Pathological anatomy and histopathology · 1991Article
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2 authors.
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Abstract
The immunoalkaline phosphatase (APAAP) technique was applied to the labelling of decalcified sections of formalin fixed, paraffin wax embedded bone marrow trephine biopsy specimens. A panel of monoclonal antibodies reactive with haemopoietic and epithelial antigens, which survive routine formalin fixation, was assessed on 72 cases of haematological malignancy (including acute and chronic leukaemias and lymphomas) showing bone marrow infiltration. The APAAP method showed clear distinct labelling of antigen positive cells without loss of antigens due to decalcification. Both normal or reactive single cells present in the sample and neoplastic cell populations could be identified morphologically and their antigenic phenotype and cellular origin, whether lymphoid or myeloid, established. The application of the APAAP method to routinely prepared paraffin wax embedded trephines has many advantages over the assessment of specially prepared cryostat sections of bone marrow.
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