Evidence map›Paper›PMID 26850219›Full record

ReviewTrends in microbiology2016

RNA Structure Duplications and Flavivirus Host Adaptation.

Sergio M Villordo, Juan M Carballeda, Claudia V Filomatori, Andrea V Gamarnik

Open access · bronzeAbstract readReview
In one paragraph

Review in Trends in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed
24.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

130 citing papers in PubMed, 188 citations in OpenAlex.

  1. Production of Viral Particles from a Chikungunya Virus Infectious Clone.Methods in molecular biology (Clifton, N.J.) · 2027
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  10. m6A epigenetic modification of viral RNA is critical for the transmission cycle of mosquito-borne flaviviruses.Proceedings of the National Academy of Sciences of the United States of America · 2026
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70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sergio M VillordoFundación Instituto Leloir-CONICET, Av. Patricias Argentinas 435, Buenos Aires 1405, Argentina.
Juan M CarballedaFundación Instituto Leloir-CONICET, Av. Patricias Argentinas 435, Buenos Aires 1405, Argentina.
Claudia V FilomatoriFundación Instituto Leloir-CONICET, Av. Patricias Argentinas 435, Buenos Aires 1405, Argentina.
Andrea V GamarnikFundación Instituto Leloir-CONICET, Av. Patricias Argentinas 435, Buenos Aires 1405, Argentina. Electronic address: agamarnik@leloir.org.ar.
Fundación Instituto Leloir · AR

Funding

MECHANISMS OF DENGUE VIRUS GENOME ENCAPSIDATION AND UNCOATINGR01AI095175 · NIAID · FUNDACION INSTITUTO LELOIR · PI GAMARNIK, ANDREA · 2011 to 2020
$1.0M
NIAID NIH HHS R01 AI095175NIAID NIH HHS R01-AI095175
6 · The paper itself

Abstract

Flaviviruses include a highly diverse group of arboviruses with a global distribution and a high human disease burden. Most flaviviruses cycle between insects and vertebrate hosts; thus, they are obligated to use different cellular machinery for their replication and mount different mechanisms to evade specific antiviral responses. In addition to coding for viral proteins, the viral genome contains signals in RNA structures that govern the amplification of viral components and participate in triggering or evading antiviral responses. In this review, we focused on new information about host-specific functions of RNA structures present in the 3' untranslated region (3' UTR) of flavivirus genomes. Models and conservation patterns of RNA elements of distinct flavivirus ecological groups are revised. An intriguing feature of the 3' UTR of insect-borne flavivirus genomes is the conservation of complex RNA structure duplications. Here, we discuss new hypotheses of how these RNA elements specialize for replication in vertebrate and invertebrate hosts, and present new ideas associating the significance of RNA structure duplication, small subgenomic flavivirus RNA formation, and host adaptation.

Indexed as

Nucleic Acid ConformationAdaptation, BiologicalAnimalsEvolution, MolecularFlavivirusGenome, ViralHost-Pathogen InteractionsHumansPhylogenyRNA, ViralRNA, Viraldengue virusflaviviruseshost adaptationRNA virus evolutionsfRNAsviral RNA structures

Identifiers

PMID26850219
PMCPMC4808370
OpenAlexW2259471848

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.