ArticleFEMS microbiology ecology2016
Evidence for plasmid-mediated salt tolerance in the human gut microbiome and potential mechanisms.
Article in FEMS microbiology ecology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 34 citations in OpenAlex.
- Global transmission of broad-host-range plasmids derived from the human gut microbiome.Nucleic acids research · 2023Article
- A plasmid network from the gut microbiome of semi-isolated human groups reveals unique and shared metabolic and virulence traits.Scientific reports · 2022Article
- Microbial evolution and transitions along the parasite-mutualist continuum.Nature reviews. Microbiology · 2021Review
- The persistence potential of transferable plasmids.Nature communications · 2020Article
- Multidrug-resistant enterobacteriaceae in coastal water: an emerging threat.Antimicrobial resistance and infection control · 2020Article
- Assessing the benefits of horizontal gene transfer by laboratory evolution and genome sequencing.BMC evolutionary biology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human gut microbiome is critical to health and wellbeing. It hosts a complex ecosystem comprising a multitude of bacterial species, which contributes functionality that would otherwise be absent from the host. Transient and commensal bacteria in the gut must withstand many stresses. The influence of mobile genetic elements such as plasmids in stress adaptation within the ecosystem is poorly understood. Using a mobilomic approach we found evidence for plasmid-mediated osmotolerance as a phenotype amongst the Proteobacteria in healthy faecal slurries. A transconjugant carrying multiple plasmids acquired from healthy faecal slurry demonstrated increased osmotolerance in the presence of metal salts, particularly potassium chloride, which was not evident in the recipient. Pyrosequencing and analysis of the total plasmid DNA demonstrated the presence of plasmid-borne osmotolerance systems (including KdpD and H-NS) which may be linked to the observed phenotype. This is the first report of a transferable osmotolerance phenotype in gut commensals and may have implications for the transfer of osmotolerance in other niches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.