ArticlePediatric nephrology (Berlin, Germany)2016
Clinical characteristics and prevalence of complications of chronic kidney disease in children: the Taiwan Pediatric Renal Collaborative study.
Article in Pediatric nephrology (Berlin, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- Acute Kidney Injury and Neurodevelopmental Outcomes in Extremely Premature Neonates: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2025Trial
- Early and Stage-Dependent Cardiopulmonary Fitness Impairment in Pediatric CKD.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Chronic Kidney Disease in Lithuanian Children: Single Center Experience.Acta medica Lituanica · 2026Article
- Plasma Thrombospondin-1 in Etiology-Specific Associations with Proteinuria Events in Pediatric Chronic Kidney Disease.Children (Basel, Switzerland) · 2025Article
- Economic burden of hospitalization for Chinese children with chronic kidney disease: a comparison between patients with and without infection.Frontiers in pediatrics · 2025Article
- Neonatal jaundice is associated with increased risks of congenital anomalies of the kidney and urinary tract and concomitant urinary tract infection.Scientific reports · 2024Article
- Associations between maternal chronic diseases and congenital anomalies of the kidney and urinary tract in offspring: a population-based cohort study.Clinical kidney journal · 2023Article
- Comparisons of EQ-5D-Y and PedsQL in pediatric patients with mild-to-moderate chronic kidney disease in longitudinal analyses.Health and quality of life outcomes · 2023Article
- Neurodevelopment After Neonatal Acute Kidney Injury in Very Preterm-Birth Children.Kidney international reports · 2023Article
- Assessment of uremic toxins in advanced chronic kidney disease patients on maintenance hemodialysis by LC-ESI-MS/MS.Metabolomics : Official journal of the Metabolomic Society · 2023Article
- Epidemiology of pediatric chronic kidney disease/kidney failure: learning from registries and cohort studies.Pediatric nephrology (Berlin, Germany) · 2022Review
- Incidence of and risk factors for short stature in children with chronic kidney disease: results from the KNOW-Ped CKD.Pediatric nephrology (Berlin, Germany) · 2021Article
- The Human Microbiome in Chronic Kidney Disease: A Double-Edged Sword.Frontiers in medicine · 2021Review
- Association between Acrylamide Metabolites and Cardiovascular Risk in Children With Early Stages of Chronic Kidney Disease.International journal of molecular sciences · 2020Article
- Association of Trimethylamine, Trimethylamine N-oxide, and Dimethylamine with Cardiovascular Risk in Children with Chronic Kidney Disease.Journal of clinical medicine · 2020Article
- The Association between Nitric Oxide Pathway, Blood Pressure Abnormalities, and Cardiovascular Risk Profile in Pediatric Chronic Kidney Disease.International journal of molecular sciences · 2019Article
- Blood Pressure Abnormalities Associated with Gut Microbiota-Derived Short Chain Fatty Acids in Children with Congenital Anomalies of the Kidney and Urinary Tract.Journal of clinical medicine · 2019Article
- Adherence to long-term use of renin-angiotensin II-aldosterone system inhibitors in children with chronic kidney disease.BMC pediatrics · 2019Article
- Gut Microbiota-Dependent TrimethylamineInternational journal of molecular sciences · 2018Article
- Mortality Risks among Various Primary Renal Diseases in Children and Adolescents on Chronic Dialysis.Journal of clinical medicine · 2018Article
Corrections and comments
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Authors and funding
7 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLittle information is available regarding the clinical characteristics and prevalence of complications in children with chronic kidney disease (CKD), especially in early disease stages. The objective of this study was to determine the clinical characteristics and prevalence of complications in children with predialytic CKD.
methodsThis multicenter, cross-sectional study enrolled children at all stages of predialytic CKD. Children who were between the ages of 1 year and 18 years and who fulfilled the clinical criteria of CKD were included in the study. Baseline demographic data, previous history, clinical characteristics, and laboratory data were collected.
resultsA total of 757 children were included in the study. The median age at the time of enrollment was 10.6 years; 397 patients (52.4 %) were males. A total of 39.0 % of the patients were in CKD stage 1, 37.6 % were in stage 2, 14.8 % were in stage 3, 3.0 % were in stage 4, and 5.5 % were in stage 5. Nonglomerular renal diseases were the primary cause of CKD, comprising 51.9 % of the patients with CKD. The age at disease onset, gender, CKD stage distribution, and proportion of co-morbidities varied between the glomerular and nonglomerular CKD cases. Anemia, hyperlipidemia, hypocalcemia, and hyperphosphatemia were more prevalent in patients with glomerular CKD. The overall prevalence of complications was as follows: uncontrolled blood pressure, 44.1 %; anemia, 34.2 %; hyperlipidemia, 44.9 %; short stature, 10.3 %; and failure to thrive, 8.2 %. Uncontrolled blood pressure (BP), anemia, and hyperlipidemia were common, even in the early CKD stages. The prevalence of CKD complications generally increased with the worsening stage of CKD.
conclusionsThis study reveals differences in CKD etiology and prevalence of specific complications according to the stage of CKD. Early recognition and awareness of complications are mandatory for clinicians during the follow-up visits of children with CKD.
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