ArticleFree radical biology & medicine2016
Persister formation in Escherichia coli can be inhibited by treatment with nitric oxide.
Article in Free radical biology & medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- The histidine kinase NahK regulates denitrification and nitric oxide accumulation through RsmA inJournal of bacteriology · 2025Article
- Mini review: Persister cell control strategies.Frontiers in pharmacology · 2025Review
- Pleiotropic actions of phenothiazine drugs are detrimental to Gram-negative bacterial persister cells.Communications biology · 2022Article
- High-Throughput Screening of a Promoter Library Reveals New Persister Mechanisms in Escherichia Coli.Microbiology spectrum · 2022Article
- Cellular Self-Digestion and Persistence in Bacteria.Microorganisms · 2021Review
- Ways to control harmful biofilms: prevention, inhibition, and eradication.Critical reviews in microbiology · 2021Review
- Monitoring Persister Resuscitation with Flow Cytometry.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Article
- A Quantitative Survey of Bacterial Persistence in the Presence of Antibiotics: Towards Antipersister Antimicrobial Discovery.Antibiotics (Basel, Switzerland) · 2020Article
- Investigating the Effects of Osmolytes and Environmental pH on Bacterial Persisters.Antimicrobial agents and chemotherapy · 2020Article
- Sublethal Paraquat Confers Multidrug Tolerance inFrontiers in microbiology · 2020Article
- Identifying Metabolic Inhibitors to Reduce Bacterial Persistence.Frontiers in microbiology · 2020Article
- The Culture Environment Influences Both Gene Regulation and Phenotypic Heterogeneity inFrontiers in microbiology · 2018Article
- Bactericidal activity of alpha-bromocinnamaldehyde against persisters in Escherichia coli.PloS one · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Bacterial persisters are phenotypic variants that survive extraordinary concentrations of antibiotics, and are thought to underlie the propensity of biofilm infections to relapse. Unfortunately many aspects of persister physiology remain ill-defined, which prevents progress toward eradicating the phenotype. Recently, we identified respiration within non-growing Escherichia coli populations as a potential target for the elimination type I persisters, which are those that arise from passage through stationary phase. Here we discovered that nitric oxide (NO) treatment at the onset of stationary phase significantly reduced type I persister formation through its ability to inhibit respiration. NO decreased protein and RNA degradation in stationary phase cells, and produced populations that were more fit for protein synthesis and growth resumption upon introduction into fresh media than untreated controls. Overall, this data shows that NO, which is a therapeutically-relevant compound, has the potential to decrease the incidence of recurrent infections from persisters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.