SynthesisPloS one2016
Serial Changes of Quadriceps and Hamstring Muscle Strength Following Total Knee Arthroplasty: A Meta-Analysis.
Synthesis in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04167163 (An Open-Label Phase 2 Study of Abaloparatide to Mitigate Distal Femoral Bone Loss Following Total Knee Arthroplasty), which is not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An Open-Label Phase 2 Study of Abaloparatide to Mitigate Distal Femoral Bone Loss Following Total Knee Arthroplasty
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The course of knee extensor strength after total knee arthroplasty: a systematic review with meta-analysis and -regression.Archives of orthopaedic and trauma surgery · 2023Pooled it
- The Time Course of Quadriceps Strength Recovery After Total Knee Arthroplasty Is Influenced by Body Mass Index, Sex, and Age of Patients: Systematic Review and Meta-Analysis.Frontiers in medicine · 2022Pooled it
- No effect of tourniquet in primary total knee arthroplasty on muscle strength, functional outcome, patient satisfaction and health status: a randomized clinical trial.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2020Trial
- Trial
- Quadriceps muscle status after medial-pivot versus ultracongruent total knee arthroplasty using localized bioimpedance analysis: a randomized exploratory study.Arthroplasty (London, England) · 2026Article
- Article
- Effect of intravenous hydrocortisone and periarticular triamcinolone acetonide injection on quadriceps strength recovery in patients undergoing total knee arthroplasty: a prospective randomised controlled trial.Knee surgery & related research · 2026Article
- Localized bioimpedance reactance as a biophysical parameter of muscle recovery following total knee arthroplasty: a prospective self-controlled study.Frontiers in physiology · 2026Article
- Loading of the artificial knee during early rehabilitation and physiotherapy : an in vivo study.Bone & joint open · 2025Article
- Impact of Resistance Exercise and Nitrate Supplementation on Muscle Function and Clinical Outcomes After Knee Osteoarthritis Surgery in Middle-Aged Women with Sarcopenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.Journal of clinical medicine · 2025Article
- Association of Physical Function, Quantity, and Quality of the Quadriceps with Postoperative Physical Activity Before Total Knee Arthroplasty.Journal of clinical medicine · 2025Article
- Comparison Between Total Hip and Knee Arthroplasty on Short-Term Performance-Based Outcomes and Factors Associated with the Improvement of Gait Function During Post-Acute Inpatient Rehabilitation.Journal of clinical medicine · 2024Article
- Article
- Responsiveness of Isokinetic Dynamometry in Patients with Osteoarthritis after Knee and Hip Arthroplasty: A Prospective Repeated-Measures Cohort Study.Healthcare (Basel, Switzerland) · 2024Article
- Knee Loading With Blood Flow Restriction Can Enhance Recovery After Total Knee Arthroplasty.Cureus · 2023Review
- Effect of knee joint weight change on knee function recovery and gait after total knee arthroplasty.BMC musculoskeletal disorders · 2022Article
- Ischemic preconditioning upregulates Mitofusin2 and preserves muscle strength in tourniquet-induced ischemia/reperfusion.Journal of orthopaedic translation · 2022Article
- Should We Use Unilateral or Bilateral Tasks to Assess Maximal and Explosive Knee Extensor Strength in Patients with Knee Osteoarthritis? A Cross-Sectional Study.Journal of clinical medicine · 2021Article
- Isokinetic Strength Test of Muscle Strength and Motor Function in Total Knee Arthroplasty.Orthopaedic surgery · 2020Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This meta-analysis was performed to analyze serial changes in thigh muscles, including quadriceps and hamstring muscles, from before to one year after total knee arthroplasty (TKA). All studies sequentially comparing isokinetic quadriceps and hamstring muscle strengths between the TKA side and the contralateral uninjured limb were included in this meta-analysis. Five studies with 7 cohorts were included in this meta-analysis. The mean differences in the strengths of quadriceps and hamstring muscles between the TKA and uninjured sides were greatest three months after surgery (26.8 N∙m, 12.8 N∙m, P<0.001), but were similar to preoperative level at six months (18.4 N∙m, 7.4 N∙m P<0.001) and were maintained for up to one year (15.9 N∙m, 4.1 N∙m P<0.001). The pooled mean differences in changes in quadriceps and hamstring strengths relative to preoperative levels were 9.2 N∙m and 4.9 N∙m, respectively, three months postoperatively (P = 0.041), but were no longer significant after six months and one year. During the year after TKA, quadriceps and hamstring muscle strengths were lowest after 3 months, recovering to preoperative level after six months, but not reaching the muscle strength on the contralateral side. Relative to preoperative levels, the difference in muscle strength between the TKA and contralateral knees was only significant at three months. Because decrease of strength of the quadriceps was significantly greater than decrease in hamstring muscle strength at postoperative three months, early rehabilitation after TKA should focus on recovery of quadriceps muscle strength.
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Registered trials
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