Evidence map›Paper›PMID 26849575›Full record

ReviewCurrent hypertension reports2016

Parasympathetic Vagal Control of Cardiac Function.

Jhansi Dyavanapalli, Olga Dergacheva, Xin Wang, David Mendelowitz

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current hypertension reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Cardiac vagal motor neurons.Current opinion in neurobiology · 2025
    Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Neuronal lineages derived from the nerve-associated Schwann cell precursors.Cellular and molecular life sciences : CMLS · 2021
    Review
  10. Article
  11. Article
  12. GPCR-dependent biasing of GIRK channel signaling dynamics by RGS6 in mouse sinoatrial nodal cells.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  13. Article
  14. Necrotizing enterocolitis: It's not all in the gut.Experimental biology and medicine (Maywood, N.J.) · 2020
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jhansi DyavanapalliDepartment of Pharmacology and Physiology, The George Washington University, 2300 Eye St NW, Washington, DC, 20037, USA.
Olga DergachevaDepartment of Pharmacology and Physiology, The George Washington University, 2300 Eye St NW, Washington, DC, 20037, USA.
Xin WangDepartment of Pharmacology and Physiology, The George Washington University, 2300 Eye St NW, Washington, DC, 20037, USA.
David MendelowitzDepartment of Pharmacology and Physiology, The George Washington University, 2300 Eye St NW, Washington, DC, 20037, USA. dmendel@gwu.edu.
George Washington University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This brief review focuses on four new topics, with novel and clinically significant consequences, concerning the powerful influence of parasympathetic activity on cardiac function. In this short summary, we will highlight very recent and important work, published in the last 3-4 years, that (1) challenges the paradigm that parasympathetic activity to the heart is involved in the control of heart rate but plays little role in other cardiac functions, (2) characterizes important long-range synaptic pathways to parasympathetic cardiac vagal neurons that are involved in "higher" brain functions (such as arousal and emotional challenges), (3) asks whether implantable chronic vagal nerve stimulation is a promising clinical tool for treating cardiovascular diseases, and (4) describes newly identified neuropeptides and other modulators that can influence the generation and maintenance of parasympathetic activity to the heart.

Indexed as

AnimalsHeartHeart RateHumansHypertensionNeuropeptidesVagus NerveNeuropeptidesCardiac functionCardiac vagal neuronsNeuropeptidesParasympathetic activityVagal nerve stimulation

Identifiers

PMID26849575
OpenAlexW2269125788

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.