ArticleThe ISME journal2016
The evolutionary dynamics of integrons in changing environments.
Article in The ISME journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 43 citations in OpenAlex.
- Integrons: the hidden architects of bacterial adaptation, evolution, and the challenges of antimicrobial resistance.Antonie van Leeuwenhoek · 2025Review
- Integrons in the Age of Antibiotic Resistance: Evolution, Mechanisms, and Environmental Implications: A Review.Microorganisms · 2024Review
- Belt and braces: Two escape ways to maintain the cassette reservoir of large chromosomal integrons.PLoS genetics · 2024Article
- Identification of integrons and gene cassette-associated recombination sites in bacteriophage genomes.Frontiers in microbiology · 2023Article
- The Application of the CRISPR-Cas System in Antibiotic Resistance.Infection and drug resistance · 2022Review
- Archaeal tyrosine recombinases.FEMS microbiology reviews · 2021Review
- Tetracycline Resistance Mediated byAntimicrobial agents and chemotherapy · 2021Article
- Article
- Engineering a CRISPR Interference System To Repress a Class 1 Integron in Escherichia coli.Antimicrobial agents and chemotherapy · 2020Article
- Horizontal Gene Transfer: From Evolutionary Flexibility to Disease Progression.Frontiers in cell and developmental biology · 2020Review
- Promoter activity of ORF-less gene cassettes isolated from the oral metagenome.Scientific reports · 2019Article
- Class 1 integrons are low-cost structures in Escherichia coli.The ISME journal · 2017Article
- Lateral Antimicrobial Resistance Genetic Transfer is active in the open environment.Scientific reports · 2017Article
- Article
- Metagenomic profiling of historic Colorado Front Range flood impact on distribution of riverine antibiotic resistance genes.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Integrons are genetic elements that are common in bacteria and are hotspots for genome evolution. They facilitate the acquisition and reassembly of gene cassettes encoding a variety of functions, including drug resistance. Despite their importance in clinical settings, the selective forces responsible for the evolution and maintenance of integrons are poorly understood. We present a mathematical model of integron evolution within bacterial populations subject to fluctuating antibiotic exposures. Bacteria carrying a functional integrase that mediates reshuffling of cassette genes and thereby modulates gene expression patterns compete with bacteria without a functional integrase. Our results indicate that for a wide range of parameters, the functional integrase can be stably maintained in the population despite substantial fitness costs. This selective advantage arises because gene-cassette shuffling generates genetic diversity, thus enabling the population to respond rapidly to changing selective pressures. We also show that horizontal gene transfer promotes stable maintenance of the integrase and can also lead to de novo assembly of integrons. Our model generates testable predictions for integron evolution, including loss of functional integrases in stable environments and selection for intermediate gene-shuffling rates in changing environments. Our results highlight the need for experimental studies of integron population biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.