Evidence map›Paper›PMID 26849302›Full record

ArticleCell stem cell2016

CDX2: Linking Cell and Patient Fates in Colon Cancer.

Eric R Fearon, Emina H Huang

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stem cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Incorporation of CEA Improves Risk Stratification in Stage II Colon Cancer.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2017
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Eric R FearonDivision of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Emina H HuangDepartment of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA; Department of Colorectal Surgery, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA. Electronic address: huange2@ccf.org.
Cleveland Clinic Lerner College of Medicine · USUniversity of Michigan · US

Funding

CDX2 TUMOR SUPPRESSOR PATHWAY DEFECTS IN COLON CANCERR01CA082223 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FEARON, ERIC R. · 1999 to 2015
$3.9M
The role of IL8 in colitis-associated tumor initiationR01CA157663 · NCI · UNIVERSITY OF FLORIDA · PI HUANG, EMINA HUI-NA · 2012 to 2016
$1.6M
The role of the colitic stem cell niche in oncogenesisR01CA142808 · NCI · UNIVERSITY OF FLORIDA · PI HUANG, EMINA HUI-NA · 2010 to 2014
$1.5M
NCI NIH HHS NCI R01 CA082223NCI NIH HHS NCI R01 CA142808NCI NIH HHS R01 CA082223NCI NIH HHS R01 CA142808NCI NIH HHS R01 CA157663
6 · The paper itself

Abstract

Administering adjuvant chemotherapy to stage II colon cancer patients is controversial due to limited benefit observed for this subpopulation. Recently, Dalerba et al. (2016) identified a subgroup of stage II patients that might benefit from adjuvant chemotherapy based on lack of CDX2 expression in their cancer stem cells.

Indexed as

Cell LineageCDX2 Transcription FactorChemotherapy, AdjuvantColonic NeoplasmsHomeodomain ProteinsHumansNeoplastic Stem CellsTrans-ActivatorsCDX2 Transcription FactorHomeodomain ProteinsTrans-Activators

Identifiers

PMID26849302
PMCPMC5497577
OpenAlexW2288265099

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.