Evidence map›Paper›PMID 26849114›Full record

ArticleAmerican journal of human genetics2016

A Robust Example of Collider Bias in a Genetic Association Study.

Felix R Day, Po-Ru Loh, Robert A Scott, Ken K Ong, John R B Perry

Abstract readLetterComment
In one paragraph

Article in American journal of human genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
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  9. Genetic regulation of fatty acid content in adipose tissue.American journal of human genetics · 2026
    Article
  10. The impact of collider bias on genetic prediction in psychotic disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  11. Article
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  16. Review
  17. Relationships between obesity and functional outcome after ischemic stroke: a Mendelian randomization study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
  18. Article
  19. Article
  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Felix R DayMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Box 285, Hills Road, Cambridge CB2 0QQ, UK.
Po-Ru LohDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
Robert A ScottMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Box 285, Hills Road, Cambridge CB2 0QQ, UK.
Ken K OngMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Box 285, Hills Road, Cambridge CB2 0QQ, UK.
John R B PerryMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Box 285, Hills Road, Cambridge CB2 0QQ, UK. Electronic address: john.perry@mrc-epid.cam.ac.uk.

Funding

Medical Research Council MC_QA137853Medical Research Council MC_U106179472Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/2
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Genetic VariationModels, GeneticQuantitative Trait, HeritableGenome-Wide Association StudyHumans

Identifiers

PMID26849114
PMCPMC4746366

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.